c(phg-isoDGR-(NMe)k) TFA

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生化分析试剂 Biochemical Assay Reagents
c(phg-isoDGR-(NMe)k) TFA;

c(phg-isoDGR-(NMe)k) TFA 是有效选择性的 α5β1 整合素配体，IC50 为 2.9 nM。

c(phg-isoDGR-(NMe)k) TFA

c(phg-isoDGR-(NMe)k) TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥5500 In-stock
5 mg ￥9800 In-stock
10 mg ￥15000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

生物活性

c(phg-isoDGR-(NMe)k) TFA is a selective and potent α5β1-integrin ligand with an IC50 of 2.9 nM[1].

IC50 Target

IC50: 2.9 nM (α5β1)[1]
体内研究
(In Vivo)

c(phg-isoDGR-(NMe)k) TFA is trimerized with the chelator TRAP and used as a positron-emission tomography tracer for monitoring α5β1 integrin expression in a M21 mouse xenograft[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

717.69

Formula

C29H42F3N9O9
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20deg;C, sealed storage, away from moisture

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

DMSO : 250 mg/mL (348.34 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.3934 mL 6.9668 mL 13.9336 mL
5 mM 0.2787 mL 1.3934 mL 2.7867 mL
10 mM 0.1393 mL 0.6967 mL 1.3934 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kapp TG, et al. N-Methylation of isoDGR Peptides: Discovery of a Selective α5β1-Integrin Ligand as a Potent Tumor Imaging Agent. J Med Chem. 2018 Mar 22;61(6):2490-2499.