荧光染料Geldanamycin-FITC

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荧光染料Dye Reagents Geldanamycin-FITC;

Geldanamycin-FITC 是一种格尔达霉素荧光探针，可用于 HSP90 抑制剂的荧光偏振分析。Geldanamycin-FITC 也可用于细胞表面 HSP90 的检测。

Geldanamycin-FITCamp;;

Geldanamycin-FITC Chemical Structure

规格 是否有货
500 μg 询价

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生物活性

Geldanamycin-FITC, a Geldanamycin fluorescent probe, can be used in a fluorescence polarization assay for HSP90 inhibitors. Geldanamycin-FITC also can be used for detection of cell surface HSP90[1][2][3].

IC50 Target[1]

HSP90

;

体外研究
(In Vitro)

The HSP90 inhibitor Geldanamycin, when conjugated with FITC (GA–FITC) is cell-membrane impermeable, binding only cell surface HSP90 and inhibiting its functions but having no effect on cytosolic HSP90[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1034.18

Formula

C55H63N5O13S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Kim J, et al. Development of a fluorescence polarization assay for the molecular chaperone Hsp90. J Biomol Screen. 2004;9(5):375‐381.

    [2]. Posfai D, et al. Identification of Hsp90 Inhibitors with Anti-Plasmodium Activity. Antimicrob Agents Chemother. 2018;62(4):e01799-17. Published 2018 Mar 27.

    [3]. Imai T, et al. Heat shock protein 90 (HSP90) contributes to cytosolic translocation of extracellular antigen for cross-presentation by dendritic cells. Proc Natl Acad Sci U S A. 2011;108(39):16363‐16368.