HKPerox-2

发表于由

HKPerox-2; 纯度: 99.03%

HKPerox-2 是一种高度选择性和敏感性的绿色荧光探针，对 H2O2 的选择性超过其他测试 ROS/RNS 的 30 倍。HKPerox-2 是 O-methyl rhodol 衍生物，通过 payne/dakin 串联反应特异识别 H2O2。

HKPerox-2amp;;

HKPerox-2 Chemical Structure

CAS No. : 2245230-79-7

规格 价格 是否有货 数量
1 mg ￥3000 In-stock
5 mg ￥9000 In-stock
10 mg ￥15500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

HKPerox-2 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus

生物活性

HKPerox-2 is an excellently selective and sensitive green fluorescent probe toward H2O2 over 30-fold other tested ROS/RNS in chemical and biological systems. HKPerox-2 is a O-methyl rhodol derivative and specifically recognize H2O2 based on a tandem payne/dakin reaction[1].

体外研究
(In Vitro)

HKPerox-2 is a O-methyl rhodol derivative and reaches a plateau within 30 min upon treatment of 100 μM H2O2, and the rate constants kobs is determined to be 2.0×10-2 s for HKPerox2[1].
HKPerox-2 (0-20 μM; 24 hours) is nontoxic to cells at working concentrations in RAW264.7 macrophages[1].
HKPerox-2 should be co-incubated with 100 μM of trichloroacetonitrile (CCl3CN, HY-Y0789) for H2O2 detection and molecular imaging.
DMSO should be avoided during H2O2 detection, as DMSO could scavenge activated H2O2 in the presence of CCl3CN.
DMF is the recommended solvent to prepare probe stock solution.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

581.53

Formula

C64H46N2O20
CAS 号

2245230-79-7
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20deg;C, protect from light

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light)
溶解性数据
In Vitro:;

DMF : 50 mg/mL (85.98 mM; ultrasonic and warming and heat to 60°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7196 mL 8.5980 mL 17.1960 mL
5 mM 0.3439 mL 1.7196 mL 3.4392 mL
10 mM 0.1720 mL 0.8598 mL 1.7196 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Sen Ye, et al. Tandem Payne/Dakin Reaction: A New Strategy for Hydrogen Peroxide Detection and Molecular Imaging. Angew Chem Int Ed Engl. 2018 Aug 6;57(32):10173-10177.