L-JNKI-1 | Cytiva思拓凡-Whatman滤纸滤膜滤器

L-JNKI-1; 纯度: 96.05%

L-JNKI-1 是一种针对 JNK 的细胞渗透性多肽抑制剂。

L-JNKI-1 Chemical Structure

规格	价格	是否有货	数量
1 mg	￥1500	In-stock
5 mg	￥3000	In-stock
10 mg	￥4500	In-stock
50 mg	￥11500	In-stock
100 mg	;	询价	;
200 mg	;	询价	;

* Please select Quantity before adding items.

L-JNKI-1 相关产品

bull;相关化合物库:

Bioactive Compound Library Plus
Peptide Library

生物活性

L-JNKI-1 is a cell-permeable peptide inhibitor specific for JNK.

IC₅₀ Target

JNK

;

体内研究
(In Vivo)

L-JNKI-1 has been shown to effectively inhibit JNK activity in in vivo studies. It is shown that Ang II induces a dose-dependent pressor response, which was significantly attenuated by JNK inhibition^[1]. It is also found that 10 μM L-JNKI-1 decreases phosphorylated c-Jun by 98% and phosphorylated Elk-1 by 100%. L-JNKI-1 is able to across the blood-brain barrier and penetrate neurons of adult mice and P5 rats within 1 h after an intraperitoneal injection^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

3822.44

Formula

C₁₆₄H₂₈₆N₆₆O₄₀

Sequence Shortening

DQSRPVQPFLNLTTPRKPRPPRRRQRRKKRG-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-80deg;C	2 years
	-20deg;C	1 year
In solvent	-80deg;C	6 months
	-20deg;C	1 month

溶解性数据

In Vitro:;

H₂O : ≥ 100 mg/mL (26.16 mM)

* “≥” means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	0.2616 mL	1.3081 mL	2.6161 mL
5 mM	0.0523 mL	0.2616 mL	0.5232 mL
10 mM	0.0262 mL	0.1308 mL	0.2616 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

参考文献

[1]. Zhou MS, et al. Role of c-Jun N-terminal kinase in the regulation of vascular tone. J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):78-83.

[2]. Borsello T, et al. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat Med. 2003 Sep;9(9):1180-6.

Animal Administration ^[1]	Rats^[1] Six-week-old male SD rats are used. The rats are injected with a bolus of JNK peptide inhibitor L-JNKI-1 (5 mg/kg) followed by infusion of JNKI 1 (5 mg/kg per hour) until the completion of the experiment. After a 30-minute infusion of JNK inhibitor, the pressor response to Ang II at the 3 doses described above is determined at 30-minute intervals^[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
参考文献	[1]. Zhou MS, et al. Role of c-Jun N-terminal kinase in the regulation of vascular tone. J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):78-83. [2]. Borsello T, et al. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat Med. 2003 Sep;9(9):1180-6.

Animal Administration
^[1]

Rats^[1]
Six-week-old male SD rats are used. The rats are injected with a bolus of JNK peptide inhibitor L-JNKI-1 (5 mg/kg) followed by infusion of JNKI 1 (5 mg/kg per hour) until the completion of the experiment. After a 30-minute infusion of JNK inhibitor, the pressor response to Ang II at the 3 doses described above is determined at 30-minute intervals^[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

参考文献

[1]. Zhou MS, et al. Role of c-Jun N-terminal kinase in the regulation of vascular tone. J Cardiovasc Pharmacol Ther. 2010 Mar;15(1):78-83.

[2]. Borsello T, et al. A peptide inhibitor of c-Jun N-terminal kinase protects against excitotoxicity and cerebral ischemia. Nat Med. 2003 Sep;9(9):1180-6.