J-2156 TFA; 纯度: 99.98%
J-2156 TFA 是一种高效,选择性的生长抑素受体 4 型 (SST4) 激动剂,对于人和大鼠 SST4 受体的 IC50 分别为 0.05 nM 和 0.07 nM。J-2156 TFA 具有抗炎作用,可以缓解大鼠同侧后爪的机械性异常性疼痛和机械性痛觉过敏。
J-2156 TFA Chemical Structure
CAS No. : 2387505-73-7
规格 | 价格 | 是否有货 | 数量 |
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Free Sample (0.1-0.5 mg) | ; | Apply now | ; |
10;mM;*;1 mL in DMSO | ¥2560 | In-stock | |
5 mg | ¥2000 | In-stock | |
10 mg | ¥3500 | In-stock | |
25 mg | ¥6500 | In-stock | |
50 mg | ¥9500 | In-stock | |
100 mg | ¥13500 | In-stock | |
200 mg | ; | 询价 | ; |
500 mg | ; | 询价 | ; |
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J-2156 TFA 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- GPCR/G Protein Compound Library
- Immunology/Inflammation Compound Library
- Neuronal Signaling Compound Library
- Targeted Diversity Library
- Peptide Library
生物活性 |
J-2156 TFA is a high potent, selective somatostatin receptor type 4 (SST4 receptor) agonist with IC50s of 0.05 nM and 0.07 nM for human and rat SST4 receptors, respectively. J-2156 TFA has anti-inflammatory activity and it is used for the relief of mechanical allodynia and mechanical hyperalgesia in the ipsilateral hindpaws in rats[1][2]. |
IC50 Target |
IC50: 0.05 nM (human SST4) and 0.07 nM (rat SST4)[1] |
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体外研究 (In Vitro) |
J-2156 TFA binds with nanomolar affinity to the human somatostatin receptor subtype 4 (hsst4: Ki=1.2 nM) and is over 400-fold subtype-selective against the other somatostatin receptors (hsst1: Ki=0.5 μM; hsst2: Ki>5 μM; hsst3: Ki=1.4 μM; hsst5: Ki=0.54 μM) in Chinese hamster ovary (CHO) cells[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
J-2156 TFA (1-10 mg/kg; i.p.; for 3 hours) of single bolus doses has anti-allodynic effect on ipsilateral and contralateral in BCIBP-rats[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
582.59 |
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Formula |
C26H29F3N4O6S |
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CAS 号 |
2387505-73-7 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Protect from light, stored under nitrogen
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen) |
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溶解性数据 |
In Vitro:;
H2O : 100 mg/mL (171.65 mM; Need ultrasonic) DMSO : 100 mg/mL (171.65 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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