Angiopep-2 hydrochloride

发表于由

Angiopep-2 hydrochloride; 纯度: 97.44%

Angiopep-2 hydrochloride 是脑肽载体。抗肿瘤药物与 Angiopep-2 肽载体的结合可提高其在脑癌中的活性.

Angiopep-2 hydrochlorideamp;;

Angiopep-2 hydrochloride Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1400 In-stock
5 mg ￥4000 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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Angiopep-2 hydrochloride 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Angiopep-2 hydrochloride is a brain peptide vector. The conjugation of anticancer agents with the Angiopep-2 peptide vector could increase their efficacy in the treatment of brain cancer[1].

体外研究
(In Vitro)

Paclitaxel is conjugated to a brain peptide vector, Angiopep-2, to provide a paclitaxel– Angiopep-2 conjugate named ANG1005. ANG1005 enters the brain to a greater extent than paclitaxel and bypasses the P-gp. ANG1005 has an antineoplastic potency similar to that of paclitaxel against human cancer cell lines[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

ANG1005 administration leads to a significant increase in the survival of mice with intracerebral implantation of U87 MG glioblastoma cells or NCI-H460 lung carcinoma cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2337.93

Formula

C104H150ClN29O31
Sequence

Thr-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-Lys-Arg-Asn-Asn-Phe-Lys-Thr-Glu-Glu-Tyr
Sequence Shortening

TFFYGGSRGKRNNFKTEEY
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (42.77 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.4277 mL 2.1386 mL 4.2773 mL
5 mM 0.0855 mL 0.4277 mL 0.8555 mL
10 mM 0.0428 mL 0.2139 mL 0.4277 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. A Régina, et al. Antitumour Activity of ANG1005, a Conjugate Between Paclitaxel and the New Brain Delivery Vector Angiopep-2. Br J Pharmacol. 2008 Sep;155(2):185-97.