GIP (1-30) amide,human acetate

发表于由

GIP (1-30) amide,human acetate; 纯度: 98.26%

GIP (1-30) amide,human acetate 是葡萄糖依赖性促胰岛素多肽 (GIP) 片段。葡萄糖依赖性促胰岛素多肽是一种肠降血糖素激素，可刺激胰岛素分泌并减少餐后血糖波动。GIP (1-30) amide,human acetate 在 10-9-10-6 M 范围内剂量依赖性地促进胰岛素分泌。

GIP (1-30) amide,human acetateamp;;

GIP (1-30) amide,human acetate Chemical Structure

规格 价格 是否有货 数量
1 mg ￥1500 In-stock
5 mg ￥4500 In-stock
10 mg ￥7500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

GIP (1-30) amide,human acetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

GIP (1-30) amide,human acetate is a glucose-dependent insulinotropic polypeptide (GIP) fragment. GIP is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions. GIP (1-30) amide,human acetate dose-dependently promotes insulin secretion over the range 10-9-10-6 M[1].

体外研究
(In Vitro)

The glucose-dependent action of Glucose-dependent insulinotropic polypeptide (GIP) on pancreatic β-cells has attracted attention towards its exploitation as a potential drug for type 2 diabetes. In a 50% aqueous trifluoroethanol solvent, GIP(1-30) amide has an α-helical structural region from F6 to A28. The structures calculated for GIP(1-30) amide remain within one family of conformations and the level of agreement between the structures demonstrated the ordered arrangement[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

3591.99

Formula

C164H244N40O49S
Sequence

Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-NH2
Sequence Shortening

YAEGTFISDYSIAMDKIHQQDFVNWLLAQK-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

DMSO : 50 mg/mL (13.92 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2784 mL 1.3920 mL 2.7840 mL
5 mM 0.0557 mL 0.2784 mL 0.5568 mL
10 mM 0.0278 mL 0.1392 mL 0.2784 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Alaña I, et al. NMR structure of the glucose-dependent insulinotropic polypeptide fragment, GIP(1-30)amide. Biochem Biophys Res Commun. 2004 Dec 3;325(1):281-6.