Nesiritide(Synonyms: 奈西立肽 Brain Natriuretic Peptide-32 human BNP-32)

发表于由

Nesiritide;(Synonyms: 奈西立肽; Brain Natriuretic Peptide-32 human; BNP-32) 纯度: 98.45%

Nesiritide (Brain Natriuretic Peptide-32 human) 是纳利尿肽受体 (NPRs) 的激动剂，其对 NPR-A 和 NPR-C 的 Kd 值分别为 7.3，13 pM。

Nesiritideamp;;(Synonyms: 奈西立肽; Brain Natriuretic Peptide-32 human; BNP-32)

Nesiritide Chemical Structure

CAS No. : 124584-08-3

规格 价格 是否有货 数量
1 mg ￥2800 In-stock
5 mg ￥8400 In-stock
10 mg ￥13000 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Nesiritide 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Nesiritide (Brain Natriuretic Peptide-32 human) is an agonist of natriuretic peptide receptors (NPRs), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively.

IC50 Target

Kd: 7.3 Pm (NPR-A), 13 pM (NPR-C)[1].
体外研究
(In Vitro)

Nesiritide (Brain Natriuretic Peptide-32 human) is an agonist of natriuretic peptide receptor (NPR), with Kd values of 7.3 and 13 pM for NPR-A and NPR-C, respectively[1]. ProBNP1-108 stimulates guanylyl cyclase-A (GC-A) to near-maximum activities but is 13-fold less potent than Nesiritide (BNP1-32). ProBNP1-108 binds human GC-A 35-fold less tightly than Nesiritide. Neither proBNP1–108 nor Nesiritide activates GC-B. The natriuretic peptide clearance receptor binds proBNP1-108 3-fold less tightly than Nesiritide. The half time for degradation of proBNP1-108 by human kidney membranes is 2.7-fold longer than for Nesiritide, and the time required for complete degradation is 6-fold longer. Nesiritide and proBNP1-108 are best fitted by first- and second-order exponential decay models, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

3464.04

Formula

C143H244N50O42S4
CAS 号

124584-08-3
Sequence

Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys-Lys-Val-Leu-Arg-Arg-His (Disulfide bridge: Cys10-Cys26)
Sequence Shortening

SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH (Disulfide bridge: Cys10-Cys26)
中文名称

奈西立肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;

H2O : ≥ 40 mg/mL (11.55 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.2887 mL 1.4434 mL 2.8868 mL
5 mM 0.0577 mL 0.2887 mL 0.5774 mL
10 mM 0.0289 mL 0.1443 mL 0.2887 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Koller KJ, et al. Molecular biology of the natriuretic peptides and their receptors. Circulation. 1992 Oct;86(4):1081-8.

    [2]. Dickey DM, et al. ProBNP(1-108) is resistant to degradation and activates guanylyl cyclase-A with reduced potency. Clin Chem. 2011 Sep;57(9):1272-8.