Protease-Activated Receptor-4(Synonyms: 蛋白酶活化的受体-4)

发表于由

Protease-Activated Receptor-4;(Synonyms: 蛋白酶活化的受体-4) 纯度: 98.14%

Protease-Activated Receptor-4 是转化生长因子受体 4 的激动剂。

Protease-Activated Receptor-4amp;;(Synonyms: 蛋白酶活化的受体-4)

Protease-Activated Receptor-4 Chemical Structure

CAS No. : 245443-52-1

规格 价格 是否有货 数量
5 mg ￥880 In-stock
10 mg ￥1550 In-stock
25 mg ￥3400 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Protease-Activated Receptor-4 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).

体外研究
(In Vitro)

GYPGKF-NH2 significantly reduces the agonistic potency of AYPGKF-NH2 by 25-fold[1]. GYPGKF-NH2 (500 μM) does not cause contraction or relaxation of the guinea pig IAS strips[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

666.77

Formula

C33H46N8O7
CAS 号

245443-52-1
Sequence

Gly-Tyr-Pro-Gly-Lys-Phe-NH2
Sequence Shortening

GYPGKF-NH2
中文名称

蛋白酶活化的受体-4
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 50 mg/mL (74.99 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.4998 mL 7.4988 mL 14.9977 mL
5 mM 0.3000 mL 1.4998 mL 2.9995 mL
10 mM 0.1500 mL 0.7499 mL 1.4998 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Moschonas IC, et al. Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand. Platelets. 2017 Mar 7:1-10. doi: 10.1080/09537104.2017.1282607. [Epub ahead of print]

    [2]. Huang SC, et al. Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincter. Regul Pept. 2014 Feb 10;189:46-50.