Urotensin II (114-124), human TFA

发表于由

Urotensin II (114-124), human TFA; 纯度: 99.76%

Urotensin II (114-124), human TFA 是一个含 11 个氨基酸的残基肽，是孤儿受体 GPR14 激动剂，是一有效血管收缩剂。

Urotensin II (114-124), human TFAamp;;

Urotensin II (114-124), human TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ￥2100 In-stock
5 mg ￥8400 In-stock
10 mg ; 询价 ;
50 mg ; 询价 ;

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Urotensin II (114-124), human TFA 相关产品

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生物活性

Urotensin II (114-124), human TFA, an 11-amino acid residue peptide, is a potent vasoconstrictor and agonist for the orphan receptor GPR14.

IC50 Target

GPR14[1]
体外研究
(In Vitro)

Human Urotensin II (U-II) binds to recombinant human GPR14 with high affinity, and the binding is functionally coupled to calcium mobilization. Human Urotensin II induces concentration-dependent increases in intracellular calcium in a HEK-293 cell line expressing human GPR14 (EC50=0:62±0.17 nM, n=6)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Human Urotensin II (U-II) markedly increases total peripheral resistance in anaesthetized non-human primates, a response associated with profound cardiac contractile dysfunction[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1502.59

Formula

C66H86F3N13O20S2
Sequence

Glu-Thr-Pro-Asp-Cys-Phe-Trp-Lys-Tyr-Cys-Val (Disulfide bridge: Cys5-Cys7)
Sequence Shortening

ETPDCFWKYCV (Disulfide bridge: Cys5-Cys7)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (66.55 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.6655 mL 3.3276 mL 6.6552 mL
5 mM 0.1331 mL 0.6655 mL 1.3310 mL
10 mM 0.0666 mL 0.3328 mL 0.6655 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Ames RS, et al. Human urotensin-II is a potent vasoconstrictor and agonist for the orphan receptor GPR14. Nature. 1999 Sep 16;401(6750):282-6.