Nemifitide diTFA(Synonyms: INN 00835 diTFA)

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Nemifitide diTFA;(Synonyms: INN 00835 diTFA) 纯度: 99.13%

Nemifitide diTFA (INN 00835 diTFA) 是一种合成的五肽抗抑郁药，具有迅速起效的潜力。Nemifitide diTFA 是黑色素细胞抑制因子 (MIF) 的肽类似物。Nemifitide diTFA 可以透过血脑屏障。

Nemifitide diTFAamp;;(Synonyms: INN 00835 diTFA)

Nemifitide diTFA Chemical Structure

CAS No. : 204992-09-6

规格 价格 是否有货 数量
10;mM;*;1 mL in Water ￥4570 In-stock
5 mg ￥2500 In-stock
10 mg ￥4500 In-stock
50 mg ￥16500 In-stock
100 mg ; 询价 ;
200 mg ; 询价 ;

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生物活性

Nemifitide diTFA (INN 00835 diTFA) is a synthetic pentapeptide antidepressant with a potential for rapid onset of action[1]. Nemifitide diTFA is a peptide analog of melanocyte-inhibiting factor (MIF)[2]. Nemifitide diTFA can cross the blood-brain barrier[3].

体外研究
(In Vitro)

Nemifitide diTFA (INN 00835 diTFA) and its active metabolite (M1) bind at micromolar concentrations to several receptors including the 5-HT2A, 5-HT2C, melanocortin MC4, MC5 and bombesin[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Nemifitide diTFA (INN 00835 diTFA; 0.3 mg/kg; IP; daily; for 14 days) significantly increases swimming in the FSL rats after just 5 days of treatment and has long-lasting effect[2].
Nemifitide diTFA (0.0125-15.0 mg/kg) significantly increases swimming in the FSL rats at both low (0.025-0.3 mg/kg) and high (3.0-15.0 mg/kg) doses but not at intermediate (0.4-2.4 mg/kg) doses[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Flinders Sensitive Line (FSL) rat weighing 280-320 g[2]
Dosage: 0.3 mg/kg
Administration: IP; daily; for 14 days
Result: Significantly increased swimming in the FSL rats after just 5 days of treatment and had long-lasting effect.

分子量

922.80

Formula

C37H45F7N10O10
CAS 号

204992-09-6
Sequence

{Fluoro-Phe}-{Hyp}-Arg-Gly-Trp-NH2
Sequence Shortening

{Fluoro-Phe}-{Hyp}-RGW-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture and light

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture and light)
溶解性数据
In Vitro:;

H2O : 250 mg/mL (270.91 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0837 mL 5.4183 mL 10.8366 mL
5 mM 0.2167 mL 1.0837 mL 2.1673 mL
10 mM 0.1084 mL 0.5418 mL 1.0837 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Kelly JP, et al. The effect of treatment with a new antidepressant, INN 00835, on platelet serotonin uptake in depressed patients. J Affect Disord. 1999 Oct;55(2-3):231-5.

    [2]. Overstreet DH, et al. Antidepressant-like effects of a novel pentapeptide, nemifitide, in an animal model of depression. Psychopharmacology (Berl). 2004 Sep;175(3):303-9.

    [3]. Montgomery SA, et al. Efficacy and safety of 30 mg/d and 45 mg/d nemifitide compared to placebo in major depressivedisorder. Int J Neuropsychopharmacol. 2006 Oct;9(5):517-28.