POT-4(Synonyms: AL-78898A)

POT-4;(Synonyms: AL-78898A) 纯度: 99.63%

POT-4 (AL-78898A),一种 Compstatin 衍生物,是补体因子 C3 激活的有效抑制剂。POT-4 可用于与年龄相关的黄斑变性的研究。

POT-4amp;;(Synonyms: AL-78898A)

POT-4 Chemical Structure

CAS No. : 934461-40-2

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POT-4 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

POT-4 (AL-78898A), a Compstatin derivative, is a potent inhibitor of complement factor C3 activation. POT-4 can be used for age-related macular degeneration research[1][2]

体外研究
(In Vitro)

A derivative of compstatin, a potent C3 inhibitor, POT-4 is a cyclic peptide that exhibits binding activity to C3, preventing cleavage to its active fragments C3a and C3b[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

1627.85

Formula

C72H102N22O18S2

CAS 号

934461-40-2

Sequence Shortening

Ac-ICV{Trp(Me)}QDWGAHRCT-NH2 (Disulfide bridge:Cys2-Cys12)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献
  • [1]. S. Kaushal, et al. Complement C3 inhibitor POT-4: Clinical Safety of Intravitreal Administration. ARVO Annual Meeting Abstract, 2009 Apr.

    [2]. Robyn Troutbeck, et al. Therapeutic targeting of the complement system in age-related macular degeneration: a review. Clin Exp Ophthalmol. Jan-Feb 2012;40(1):18-26.