Cyclotraxin B

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Cyclotraxin B; 纯度: 99.87%

Cyclotraxin B 是一种环肽，是一种高效且选择性的 TrkB 抑制剂，且不会改变 BDNF 的结合。Cyclotraxin B 非竞争性地抑制 BDNF 诱导的 TrkB 活性，IC50 值为 0.30 nM。Cyclotraxin B 可以穿越血脑屏障，并具有止痛和抗焦虑的行为作用。

Cyclotraxin Bamp;;

Cyclotraxin B Chemical Structure

CAS No. : 1203586-72-4

规格 价格 是否有货 数量
1 mg ￥2600 In-stock
5 mg ￥7800 In-stock
10 mg ￥12500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Cyclotraxin B 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Cyclotraxin B, a cyclic peptide, is a highly potent and selective TrkB inhibitor without altering the binding of BDNF. Cyclotraxin B non-competitively inhibits BDNF-induced TrkB activity with an IC50  of  0.30 nM. Cyclotraxin B can crosse the blood-brain-barrier and has analgesic and anxiolytic-like behavioral effects[1][2][3].

分子量

1200.37

Formula

C48H73N13O17S3
CAS 号

1203586-72-4
Sequence Shortening

CNPMGYTKEGC (Disulfide bridge:Cys1-Cys11)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Stored under nitrogen

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (stored under nitrogen)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (83.31 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8331 mL 4.1654 mL 8.3308 mL
5 mM 0.1666 mL 0.8331 mL 1.6662 mL
10 mM 0.0833 mL 0.4165 mL 0.8331 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (stored under nitrogen)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Maxime Cazorla, et al. Cyclotraxin-B, the first highly potent and selective TrkB inhibitor, has anxiolytic properties in mice. PLoS One. 2010 Mar 19;5(3):e9777.

    [2]. Luis Constandil, et al. Cyclotraxin-B, a new TrkB antagonist, and glial blockade by propentofylline, equally prevent and reverse cold allodynia induced by BDNF or partial infraorbital nerve constriction in mice. J Pain. 2012 Jun;13(6):579-89.

    [3]. Michel M M Verheij, et al. Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex. J Neurosci. 2016 Aug 3;36(31):8149-59.