Apraglutide(Synonyms: FE 203799)

发表于由

Apraglutide;(Synonyms: FE 203799) 纯度: 98.45%

Apraglutide (FE 203799) 是一种合成的33-氨基酸肽和长效的 GLP-2类似物，能够增强全回肠切除的新生短肠综合征小猪的适应性和线性肠生长。

Apraglutideamp;;(Synonyms: FE 203799)

Apraglutide Chemical Structure

CAS No. : 1295353-98-8

规格 价格 是否有货 数量
1 mg ￥1200 In-stock
5 mg ￥3300 In-stock
10 mg ￥5200 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

Apraglutide 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • Clinical Compound Library Plus
  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Apraglutide (FE 203799), a synthetic 33-amino-acid peptide and a long-acting GLP-2 analogue, enhances adaptation and linear intestinal growth in a neonatal piglet model of short bowel syndrome with total resection of the ileum[1].

体内研究
(In Vivo)

Apraglutide (FE 203799; 5 mg/kg/dose, subcutaneously, twice on days 0 and 4 postsurgery) treated piglets are healthy, have significant lower fecal fat and energy losses and exhibite intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth on day 7[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NewbornDuroc piglets, 2–5 days old and weighing between 2-2.6 kg[1].
Dosage: 5 mg/kg/dose.
Administration: Subcutaneously, twice on days 0 and 4 postsurgery.
Result: On day 7, treated piglets were healthy, had significant lower fecal fat and energy losses and exhibited intestinal lengthening, greater small-intestinal weight, longer villus height, and greater crypt depth.

Clinical Trial

分子量

3765.25

Formula

C172H263N43O52
CAS 号

1295353-98-8
Sequence Shortening

HGDGSFSDEX FTILDLLAAR DFINWLIQTK ITD-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
参考文献

  • [1]. Slim GM, et al. Novel Long-Acting GLP-2 Analogue, FE 203799 (Apraglutide), Enhances Adaptation and Linear Intestinal Growth in a Neonatal Piglet Model of Short Bowel Syndrome with Total Resection of the Ileum. JPEN J Parenter Enteral Nutr. 2019 Jan 6.