NP213 TFA; 纯度: 96.22%
NP213 TFA 是一种快速、新颖、的合成抗菌肽 (AMP),具有抗真菌 (anti-fungal) 活性。NP213 TFA 以真菌胞质膜为靶点,通过对膜的扰动和破坏发挥作用。NP213 对甲真菌感染有效且耐受性好。
NP213 TFA Chemical Structure
规格 | 价格 | 是否有货 | 数量 |
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10;mM;*;1 mL in DMSO | ¥5710 | In-stock | |
5 mg | ¥2700 | In-stock | |
10 mg | ¥4300 | In-stock | |
25 mg | ¥7600 | In-stock | |
50 mg | ; | 询价 | ; |
100 mg | ; | 询价 | ; |
* Please select Quantity before adding items.
NP213 TFA 相关产品
bull;相关化合物库:
- Bioactive Compound Library Plus
- Anti-Infection Compound Library
- Antifungal Compound Library
- Peptide Library
生物活性 |
NP213 TFA is a rapidly acting, novel, first-in-class synthetic antimicrobial peptide (AMP), has anti-fungal activities. NP213 TFA targets the fungal cytoplasmic membrane and plays it role via membrane perturbation and disruption. NP213 TFA is effective and well-tolerated in resolving nail fungal infections[1][2]. |
IC50 Target |
IC50: fungal[1] |
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体外研究 (In Vitro) |
NP213 (500-1000 μg/mL; 18 hours) increases the number of PI-stained T. rubrum NCPF0118 cells in samples. This results suggests that NP213 is fungicidal and the mechanisms of action involved membrane permeabilization[1].NP213 is against T. rubrum NCPF0118, shows different MIC values against T. rubrum NCPF0118, and the MICs varies depending on the source of the keratin. The MIC values are 16-32 mg/L, 125 mg/L, and 250 mg/L for NP213 in 1640 media containing human nail Keratin, human skin Keratin and Lamb’s wool Keratin, respectively[1].NP213 TFA (2-3 hours; 0-8 μg/ml) has great activity against clinically relevant yeast, including candida spp, Cryptococcus spp and Trichosporon spp. For all 122 yeast isolates, with the median MIC100 values of 1-2 µg/ml[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity Assay[3]
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体内研究 (In Vivo) |
NP213 TFA (25 mg/kg) is well tolerated in mice. In Murine models of acute disseminated candidiasis, NP213 is tolerated and efficacious and exhibits a half-life of approximately 4.5 h[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
1207.32 |
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Formula |
C44H85F3N28O9 |
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Sequence |
Cyclo-Arg-Arg-Arg-Arg-Arg-Arg-Arg |
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Sequence Shortening |
Cyclo-RRRRRRR |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Protect from light, stored under nitrogen
*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (protect from light, stored under nitrogen) |
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溶解性数据 |
In Vitro:;
H2O : 100 mg/mL (82.83 mM; Need ultrasonic) DMSO : 100 mg/mL (82.83 mM; Need ultrasonic) 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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