HS024 TFA

HS024 TFA; 纯度: 99.63%

HS024 是一种选择性的 MC4 受体拮抗剂,对 MC4、MC5、MC3 和 MC1 的 Ki 分别为 0.29、3.29、5.45 和 18.6 nM。HS024 增加食物摄入。

HS024 TFAamp;;

HS024 TFA Chemical Structure

规格 价格 是否有货 数量
1 mg ¥1400 In-stock
5 mg ¥3200 In-stock
10 mg ¥5200 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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HS024 TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • GPCR/G Protein Compound Library
  • Neuronal Signaling Compound Library
  • Peptide Library

生物活性

HS024 is a selective MC4 receptor antagonist, with Kis of 0.29, 3.29, 5.45, 18.6 nM for MC4, MC5, MC3, and MC1, respectively. HS024 increase food intake[1].

分子量

1380.52

Formula

C60H80F3N19O12S2

Sequence Shortening

Ac-C-{Nle}-RH-{D-2Nal}-RWGC-NH2 (Disulfide bridge:Cys1-Cys9)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)

溶解性数据
In Vitro:;

H2O : 50 mg/mL (36.22 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7244 mL 3.6218 mL 7.2436 mL
5 mM 0.1449 mL 0.7244 mL 1.4487 mL
10 mM 0.0724 mL 0.3622 mL 0.7244 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。

参考文献
  • [1]. Kask A, et al. Discovery of a novel superpotent and selective melanocortin-4 receptor antagonist (HS024): evaluation in vitro and in vivo. Endocrinology. 1998;139(12):5006-5014.