WKYMVM-NH2 TFA

发表于由

WKYMVM-NH2 TFA; 纯度: 98.00%

WKYMVM-NH2 TFA 是有效的 N-甲酰肽受体 FPR1 和 FPRL1/2 的激动剂，同时可以激活一些白细胞效应功能，如趋化性、激活补体受体-3 及 NADPH 氧化酶。

WKYMVM-NH2 TFAamp;;

WKYMVM-NH2 TFA Chemical Structure

CAS No. : 1435781-74-0

规格 价格 是否有货 数量
1 mg ￥1100 In-stock
5 mg ￥2400 In-stock
10 mg ￥3800 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

* Please select Quantity before adding items.

WKYMVM-NH2 TFA 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Immunology/Inflammation Compound Library
  • Pyroptosis Compound Library
  • Peptide Library

生物活性

WKYMVM-NH2 TFA is a potent N-formyl peptide receptor (FPR1) and FPRL1/2 agonist, also activates several leukocyte effector functions such as chemotaxis, mobilization of complement receptor-3, and activation of the NADPH oxidase[1][2][3].

体外研究
(In Vitro)

WKYMVM-NH2 TFA (10-1000 nM; 24 hours) induces Caco-2 cells proliferation[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: Caco-2 cells (the intestinal epithelial cells)
Concentration: 0 nM, 10 nM, 100 nM, 1000 nM
Incubation Time: 24 hours
Result: Induced cell proliferation.

体内研究
(In Vivo)

WKYMVM-NH2 TFA (8 mg/kg; six times; for 5 days) ameliorates DSS-induced ulcerative colitis[3].
WKYMVM-NH2 TFA affects cytokine (IL-17, IFN-γ, IL-6, IL-1β and TNF-α) profiles in the DSS colitis model[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old C57BL/6 mice, DSS model[3]
Dosage: 8 mg/kg
Administration: Subcutaneously injected, six subcutaneous administrations at 12-h intervals, for 5 days
Result: Attenuated the DSS-induced increase in the bleeding score and the stool score.

分子量

970.13

Formula

C43H62F3N9O9S2
CAS 号

1435781-74-0
Sequence Shortening

WKYMVM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 12.5 mg/mL (12.88 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.0308 mL 5.1539 mL 10.3079 mL
5 mM 0.2062 mL 1.0308 mL 2.0616 mL
10 mM 0.1031 mL 0.5154 mL 1.0308 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Christophe T, et al. The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2. J Biol Chem. 2001 Jun 15;276(24):21585-93.

    [2]. Christophe T, et al. Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4. Scand J Immunol. 2002 Nov;56(5):470-6.

    [3]. Sang Doo Kim, et al. The immune-stimulating peptide WKYMVm has therapeutic effects against ulcerative colitis. Exp Mol Med. 2013 Sep; 45(9): e40.