CCP peptide

CCP peptide;

CCP peptide 是一种合成的环状瓜氨酸化肽 (CCP),用作血清学检测抗 CCP 抗体的底物。CCP peptide 可作为自身抗体的靶标,对类风湿关节炎 (RA) 具有很高的特异性。

CCP peptideamp;;

CCP peptide Chemical Structure

CAS No. : 277748-59-1

规格 是否有货
100 mg ; 询价 ;
250 mg ; 询价 ;
500 mg ; 询价 ;

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CCP peptide 的其他形式现货产品:

CCP peptide TFA

生物活性

CCP peptide is a synthetic cyclic citrullinated peptide (CCP) and used as the substrate for detecting anti-CCP antibodies serologically. CCP peptide functions as a target for autoantibodies with a very high specificity for rheumatoid arthritis (RA)[1][2].

体内研究
(In Vivo)

CCP peptide is used as a new antigenic substrate in anti-CCP ELISA to detect anti-citrullinated protein antibodies (ACPAs). The anti-CCP ELISA is extremely specific (98%), with a reasonable sensitivity (68%). The anti-CCP ELISA is very useful for diagnostic and therapeutic strategies in rheumatoid arthritis (RA)[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

2341.47

Formula

C87H145N41O32S2

CAS 号

277748-59-1

Sequence

His-Gln-Cys-His-Gln-Glu-Ser-Thr-{Cit}-Gly-Arg-Ser-Arg-Gly-Arg-Cys-Gly-Arg-Ser-Gly-Ser (Disulfide bridge: Cys3-Cys16)

Sequence Shortening

HQCHQEST-{Cit}-GRSRGRCGRSGS (Disulfide bridge: Cys3-Cys16)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Puszczewicz M, et al. Role of anti-citrullinated protein antibodies in diagnosis and prognosis of rheumatoid arthritis. Arch Med Sci. 2011 Apr;7(2):189-94.

    [2]. Söderlin MK, et al. Antibodies against cyclic citrullinated peptide (CCP) and levels of cartilage oligomeric matrix protein (COMP) in very early arthritis: relation to diagnosis and disease activity. Scand J Rheumatol. 2004;33(3):185-8.

    [3]. Schellekens GA, et al. The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum. 2000 Jan;43(1):155-63.