IYPTNGYTR acetate

发表于由

IYPTNGYTR acetate; 纯度: 99.41%

IYPTNGYTR acetate，一种脱酰胺敏感的特征肽，是曲妥珠单抗 (Trastuzumab) 的脱酰胺产物。 IYPTNGYTR acetate 可用于监测体内曲妥珠单抗的代谢。

IYPTNGYTR acetateamp;;

IYPTNGYTR acetate Chemical Structure

规格 价格 是否有货 数量
5 mg ￥2500 In-stock
10 mg ￥4500 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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IYPTNGYTR acetate 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Metabolism/Protease Compound Library
  • Drug Metabolite Library
  • Peptide Library

生物活性

IYPTNGYTR acetate, a deamidation-sensitive signature peptide, is a deamidation product of Trastuzumab. IYPTNGYTR acetate can be used to monitor in vivo Trastuzumab metabolism[1].

体外研究
(In Vitro)

IYPTNGYTR is deamidated at pH 7.5 and above, with a higher deamidation rate when the pH increases[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1144.23

Formula

C51H77N13O17
Sequence Shortening

IYPTNGYTR
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 125 mg/mL (109.24 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8740 mL 4.3698 mL 8.7395 mL
5 mM 0.1748 mL 0.8740 mL 1.7479 mL
10 mM 0.0874 mL 0.4370 mL 0.8740 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Bults P, et, al. LC-MS/MS-Based Monitoring of In Vivo Protein Biotransformation: Quantitative Determination of Trastuzumab and Its Deamidation Products in Human Plasma. Anal Chem. 2016 Feb 2;88(3):1871-7.