Urotensin I(Synonyms: Catostomus urotensin I)

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Urotensin I;(Synonyms: Catostomus urotensin I)

Urotensin I (Catostomus urotensin I) 是一种类 CRF 样肽，可作为CRF 受体激动剂，在细胞实验中，对人 CRF1，CRF2 和大鼠 CRF2α 受体的 pEC50 值分别为 11.46，9.36 和 9.85，对 hCRF1，rCRF2α 和 mCRF2β 受体的 Ki 值分别为 0.4，1.8 和 5.7 nM。

Urotensin Iamp;;(Synonyms: Catostomus urotensin I)

Urotensin I Chemical Structure

CAS No. : 83930-33-0

规格 价格 是否有货
500 μg ￥2600 询问价格 货期
1 mg ￥4500 询问价格 货期
5 mg ￥13500 询问价格 货期

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Urotensin I 的其他形式现货产品:

Urotensin I TFA

生物活性

Urotensin I (Catostomus urotensin I), a CRF-like neuropeptide, acts as an agonist of CRF receptor with pEC50s of 11.46, 9.36 and 9.85 for human CRF1, human CRF2 and rat CRF2α receptors in CHO cells, and Kis of 0.4, 1.8, and 5.7 nM for hCRF1, rCRF2α and mCRF2β receptors, respectively[1][2].

IC50 Target

pEC50: 11.46 (human CRF1, CHO cells), 9.36 (human CRF2, CHO cells), 9.85 (rat CRF2α, CHO cells)[1]
Ki: 0.4 nM (hCRF1, cell assay), 1.8 nM (rCRF2α, cell assay), and 5.7 nM (mCRF2β, cell assay)[2]
体外研究
(In Vitro)

Urotensin I is 2-3 times more potent than CRF or sauvagine in stimulating ACTH release from a superfused goldfish anterior pituitary cell column[3].
Rat tail artery strips were incubated in the presence of 4 x 10(-3) M theophylline and Urotensin I (UI). At the concentrations of 1.50, 7.50 mU/ml but not of 0.75 mU/ml Urotensin I, the content of cAMP increased significantly[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Intraperitoneal injections of urotensin I, a CRF-like neuropeptide isolated from the caudal neurosecretory system of the teleost Catostomus commersoni, ovine CRF and sauvagine all produced significant increases in circulating levels of plasma cortisol in goldfish in which endogenous ACTH secretion was suppressed with betamethasone[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

4869.46

Formula

C210H340N62O67S2
CAS 号

83930-33-0
Sequence

Asn-Asp-Asp-Pro-Pro-Ile-Ser-Ile-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Asn-Met-Ile-Glu-Met-Ala-Arg-Ile-Glu-Asn-Glu-Arg-Glu-Gln-Ala-Gly-Leu-Asn-Arg-Lys-Tyr-Leu-Asp-Glu-Val-NH2
Sequence Shortening

NDDPPISIDLTFHLLRNMIEMARIENEREQAGLNRKYLDEV-NH2
中文名称

硬骨鱼紧张肽I
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Smart D, et al. Characterisation using microphysiometry of CRF receptor pharmacology. Eur J Pharmacol. 1999 Aug 27;379(2-3):229-35.

    [2]. Reul JM, et al. Corticotropin-releasing factor receptors 1 and 2 in anxiety and depression. Curr Opin Pharmacol. 2002 Feb;2(1):23-33.

    [3]. Fryer J, et al. Urotensin I, a CRF-like neuropeptide, stimulates acth release from the teleost pituitary. Endocrinology. 1983;113(6):2308-2310.

    [4]. Gerritsen ME, et al. Urotensin I effects on intracellular content of cyclic AMP in the rat tail artery. Eur J Pharmacol. 1979;60(2-3):211-220.