Eledoisin(Synonyms: Eledone peptide)

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Eledoisin;(Synonyms: Eledone peptide) 纯度: 98.73%

Eledoisin (Eledone peptide) 是 NK2 和 NK3 受体的特异性激动剂。

Eledoisinamp;;(Synonyms: Eledone peptide)

Eledoisin Chemical Structure

CAS No. : 69-25-0

规格 价格 是否有货 数量
1 mg ￥600 In-stock
5 mg ￥2500 In-stock
10 mg ￥4200 In-stock
50 mg ; 询价 ;
100 mg ; 询价 ;

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Eledoisin 相关产品

bull;相关化合物库:

  • Bioactive Compound Library Plus
  • Peptide Library

生物活性

Eledoisin (Eledone peptide) is a specific agonist of NK2 and NK3 receptors.

IC50 Target

NK2 and NK3 receptors[1].
体外研究
(In Vitro)

Eledoisin (Eledone peptide) increases the value recorded under basal conditions by 24.5±3.7%; this stimulation is significantly (P<0.01) lowered to 13.1±1.9% by the simultaneous presence of CP99994. The same protocol is also used to characterize the sensitivity of Eledoisin stimulation to 0.1 μM SR48968 or 0.1 μM SB222200. SR48968 significantly (P < 0.01) lower the stimulation by Eledoisin, while SB222200 has no effect. Eledoisin stimulation is reduced by CP99994 and SR48968, NK1 and NK2 antagonists, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Eledoisin (Eledone peptide; 0.1-1 nmol/kg) injected into rats produces a biphasic cardiovascular response that consists of an initial fall of systemic blood pressure (8-15 mm Hg) followed by a rise (20-22 mm Hg). Intracerebroventricular injection of Eledoisin produces an enhancement of grooming and scratching behavior in mice[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1188.40

Formula

C54H85N13O15S
CAS 号

69-25-0
Sequence

{Glp}-Pro-Ser-Lys-Asp-Ala-Phe-Ile-Gly-Leu-Met-NH2
Sequence Shortening

{Glp}-PSKDAFIGLM-NH2
中文名称

章鱼唾腺精
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -80deg;C 2 years
-20deg;C 1 year
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 18.15 mg/mL (15.27 mM; Need ultrasonic and warming)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.8415 mL 4.2073 mL 8.4147 mL
5 mM 0.1683 mL 0.8415 mL 1.6829 mL
10 mM 0.0841 mL 0.4207 mL 0.8415 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Lippe C, et al. Eledoisin and Kassinin, but not Enterokassinin, stimulate ion transport in frog skin. Peptides. 2004 Nov;25(11):1971-5.

    [2]. Severini C, et al. The tachykinin peptide family. Pharmacol Rev. 2002 Jun;54(2):285-322.