GsMTx4

发表于由

GsMTx4;

GsMTx4 是一种蜘蛛毒液肽，选择性地抑制属于 Piezo 和 TRP 通道家族的阳离子可渗透的机械敏感性通道(MSCs)。GsMTx4 是一种重要的药理学工具，用于鉴定兴奋性 MSCs 在正常生理学和病理学中的作用。GsMTx4 显着减弱膀胱机能亢进。

GsMTx4amp;;

GsMTx4 Chemical Structure

CAS No. : 1209500-46-8

规格 价格 是否有货
500 μg ￥2700 询问价格 货期
1 mg ￥5000 询问价格 货期
5 mg ￥18000 询问价格 货期

* Please select Quantity before adding items.

GsMTx4 的其他形式现货产品:

GsMTx4 TFA

生物活性

GsMTx4 is a spider venom peptide that selectively inhibits cation-permeable mechanosensitive channels (MSCs) belonging to the Piezo and TRP channel families. GsMTx4 is an important pharmacological tool for identifying the role of these excitatory MSCs in normal physiology and pathology[1]. GsMTx4 significantly attenuates bladder hyperactivity[2].

IC50 Target

MSCs[1]
分子量

4101.89

Formula

C185H279N49O45S6
CAS 号

1209500-46-8
Sequence Shortening

GCLEFWWKCNPNDDKCCRPKLKCSKLFKLCNFSF
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Gnanasambandam R, et al. GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels. Biophys J. 2017 Jan 10;112(1):31-45.

    [2]. Liu Q, et al. Increased Piezo1 channel activity in interstitial Cajal-like cells induces bladder hyperactivity by functionally interacting with NCX1 in rats with cyclophosphamide-induced cystitis. Exp Mol Med. 2018 May 7;50(5):60.