Protirelin;(Synonyms: 普罗瑞林; Thyrotropin-releasing-hormone; TRH)
Protirelin 是一种高度保守的神经肽,发挥促甲状腺激素 (TSH) 水平的激素控制作用,及神经调节功能。
Protirelin Chemical Structure
CAS No. : 24305-27-9
规格 | 是否有货 | ||
---|---|---|---|
5 mg | 询价 | ||
10 mg | 询价 | ||
25 mg | 询价 |
* Please select Quantity before adding items.
生物活性 |
Protirelin is a highly conserved neuropeptide that exerts the hormonal control of thyroid-stimulating hormone (TSH) levels as well as neuromodulatory functions. |
|
---|---|---|
IC50 Target |
|
|
体内研究 (In Vivo) |
Protirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes, and may ancestrally have been involved in the control of postembryonic growth and reproduction[1]. The effect of the thyrotropin-releasing hormone (Protirelin, TRH), one of the hypothalamic releasing hormones, on body temperature is investigated in the rat. Protirelin, in doses of 1, 5, 10 and 20 mg/kg, is injected intraperitoneally to male Wistar rats weighing 200-250 g. Protirelin causes a temporary rise in body temperature dose-dependently. The thyroidectomized rats injected 20 mg/kg of Protirelin which induces a significant hyperthermia in the sham-operated animals, fail to show a rise in body temperature. The present results suggest that a release of thyroid hormone might participate in the hyperthermic action of Protirelin[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
|
分子量 |
362.38 |
|
Formula |
C16H22N6O4 |
|
CAS 号 |
24305-27-9 |
|
Sequence |
{pGlu}-His-Pro-NH2 |
|
Sequence Shortening |
{pGlu}-HP-NH2 |
|
中文名称 |
普罗瑞林 |
|
运输条件 |
Room temperature in continental US; may vary elsewhere. |
|
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
|
参考文献 |
|
Animal Administration [2] |
Rats[2] MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
---|---|
参考文献 |
|