PD-1/PD-L1-IN 3 TFA

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PD-1/PD-L1-IN 3 TFA;

PD-1/PD-L1-IN 3 TFA，一种大环肽，是一种有效和选择性的 PD-1/PD-L1 和 CD80/PD-L1 的相互作用抑制剂。PD-1/PD-L1-IN 3 TFA 通过与 PD-L1 结合来干扰 PD-L1 与 PD-1 和 CD80 的结合，IC50 值分别为 5.60 nM 和 7.04 nM。PD-1/PD-L1-IN 3 TFA 可用于各种疾病的研究，包括癌症和传染病。详细信息请参考专利文献 WO2014151634A1 中的化合物 No.1。

PD-1/PD-L1-IN 3 TFAamp;;

PD-1/PD-L1-IN 3 TFA Chemical Structure

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生物活性

PD-1/PD-L1-IN 3 TFA, a macrocyclic peptide, is a potent and selective inhibitor of the PD-1/PD-L1 and CD80/PD-L1 interactions extracted from patent WO2014151634A1, compound No.1. PD-1/PD-L1-IN 3 TFA interferes with PD-L1 binding to PD-1 and CD80 by binding to PD-L1, with IC50s of 5.60 nM and 7.04 nM, respectively. PD-1/PD-L1-IN 3 TFA can be used for the research of various diseases, including cancer and infectious diseases[1].

IC50 Target

IC50: 5.60 nM (PD-1/PD-L1); 7.04 nM (CD80/PD-L1)[1]
体外研究
(In Vitro)

PD-1/PD-L1-IN 3 (0.1 nM-10 μM) inhibits the binding of PD-1 and CD80 to PD-L1, with IC50s of 5.60 nM and 7.04 nM[1].
PD-1/PD-L1-IN 3 blocks the binding of recombinant PD-L1-Ig to Jurkat-PD-1 cells, and also block binding of recombinant PD-1-Ig to either L2987 or LK35.2-hPD-L1, with IC50s of 26 nM, 12 nM, and 3.5 nM, respectively[1].
PD-1/PD-L1-IN 3 (0.001-100 μM) promotes IFN secretion by CMV-specific T cells in a dose-dependent manner, with an EC50 of 400 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1966.19

Formula

C91H127F3N24O20S
Sequence Shortening

Maa-FANPHL-Sar-WSW-Nle-Nle-RCG (Disulfide bridge: Maa1-Cys15)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. MILLER, Michael Matthew, et al. Macrocyclic inhibitors of the pd-1/pd-l1 and cd80(b7-1)/pd-l1 protein/protein interactions. WO2014151634A1.