Ziconotide(Synonyms: SNX-111)

发表于由

Ziconotide;(Synonyms: SNX-111)

Ziconotide (SNX-111) 是一种肽，是一种有效且选择性的 N 型钙通道 (N-type calcium channels) 拮抗剂阻断剂。Ziconotide 减少突触传递，并可用于慢性疼痛研究。

Ziconotideamp;;(Synonyms: SNX-111)

Ziconotide Chemical Structure

CAS No. : 107452-89-1

规格 是否有货
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Ziconotide 的其他形式现货产品:

Ziconotide acetate

生物活性

Ziconotide (SNX-111), a peptide, is a potent and selective block of N-type calcium channels antagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research[1].

IC50 Target[1]

N-Type Ca2+ Channel

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体外研究
(In Vitro)

Most native cells express a variety of different calcium channels and as a result, Ziconotide only partially reduces high-voltage-activated calcium currents in differentiated human neuroblastoma IMR32 cells, rat superior cervical ganglion neurons, and rat hippocampal neurons. Ziconotide also reduces calcium currents that result from expression of the α1B subunit in HEK cells, tsa-201 cells, and Xenopus laevis oocytes[1].
Ziconotide delivers its antinociceptive efficacy by reducing the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, thereby inhibiting pain signal transmission[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Ziconotide (i.t.; 25-100 pmol/site; 5 μL; on the 4 th, 10 th, 15 th, 20 th, and 24 th days) reduces the levels of IL-1β and IL-23 in the CNS, as well as IL-17 production in the spleen, 25 days after MOG35-55-elicited EAE, in the mouse model of experimental autoimmune encephalomyelitis (EAE)[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female C57BL/6mice (18-22 g, 6-8 weeks old) injected with myelin oligodendrocytes glycoprotein[2]
Dosage: 25 pmol/site, 50 pmol/site, 100 pmol/site
Administration: Intrathecal injection; on the 4 th, 10 th, 15 th, 20 th, and 24 th days
Result: Significantly reduced the mechanical hypersensitivity in animals with EAE.

Clinical Trial

分子量

2639.13

Formula

C102H172N36O32S7
CAS 号

107452-89-1
Sequence Shortening

CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (Disulfide bridge:Cys1-Cys16;Cys8-Cys20;Cys15-Cys25)
中文名称

齐考诺肽
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Joseph G McGivern, et al. Ziconotide: a review of its pharmacology and use in the treatment of pain. Neuropsychiatr Dis Treat. 2007 Feb;3(1):69-85.

    [2]. Rodrigo B M Silva, et al. Beneficial Effects of the Calcium Channel Blocker CTK 01512-2 in a Mouse Model of Multiple Sclerosis. Mol Neurobiol. 2018 Dec;55(12):9307-9327.