CHIKV-IN-3;
CHIKV-IN-3 是一种有效的针对 CHIKV-122508 和 CHIKV-6708 的低通道抑制剂，其 EC50 值分别为 1.55 和 0.14 µM。CHIKV-IN-3 作用于宿主细胞以干扰病毒复制。CHIKV-IN-3 表现出极小的细胞毒性 (CC50 > 100 µM)。预防作用。
CHIKV-IN-3 Chemical Structure
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| 100 mg | ; | 询价 | ; |
| 250 mg | ; | 询价 | ; |
| 500 mg | ; | 询价 | ; |
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| 生物活性 |
CHIKV-IN-3 is a potent against two low-passage CHIKV inhibitor with EC50 values of 1.55 and 0.14 µM for CHIKV-122508 and CHIKV-6708, respectively. CHIKV-IN-3 acts on the host cells to interfere with the viral replication. CHIKV-IN-3 displays minimal cytotoxic liability(CC50 > 100 µM). Prophylactic effect[1]. |
IC50 Target |
EC50: 1.55 µM (CHIKV-122508); 0.14 µM (CHIKV-6708)[1] |
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| 体外研究 (In Vitro) |
CHIKV-IN-3 (compound (E)-42; HeLa CCL2 cells; 0.1-100 µM; 24 hours) inhibits the Chikungunya virus (CHIKV) replication with an EC50 of 1.55 µM and demonstrates low cytotoxicity (CC50=129.6 µM)[1]. CHIKV-IN-3 (HeLa CCL2 cells; 20, 40, 80 µM; 24 hours) shows the highest degree of inhibition with approximately 3.9-log reduction in viral titre (ca. 99.99% inhibition) at 80 µM[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Cell Cytotoxicity Assay[1]
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| 分子量 |
383.95 |
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| Formula |
C24H30ClNO |
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| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
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| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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| 参考文献 |
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