Prosaptide Tx14(A) TFA

Prosaptide Tx14(A) TFA;

Prosaptide Tx14(A) TFA 是一种 prosaposin 衍生肽,是一种有效的 GPR37L1GPR37 激动剂,EC50 分别为 5 和 7 nM。Prosaptide Tx14(A) TFA 增加 Schwann 细胞 ERK1 和 ERK2 的磷酸化。

Prosaptide Tx14(A) TFAamp;;

Prosaptide Tx14(A) TFA Chemical Structure

规格 是否有货
100 mg ; 询价 ;
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Prosaptide Tx14(A) TFA 的其他形式现货产品:

Prosaptide Tx14(A)

生物活性

Prosaptide Tx14(A) TFA, a prosaposin-derived peptide, is a potent GPR37L1 and GPR37 agonist with EC50s of 5 and 7 nM, respectively. Prosaptide Tx14(A) TFA increases both ERK1 and ERK2 phosphorylation in Schwann cells[1][2].

体外研究
(In Vitro)

Prosaptide Tx14(A) TFA promotes the endocytosis of GPR37 and GPR37L1, bound to both receptors and activated signaling in a GPR37- and GPR37L1-dependent manner. Prosaptide Tx14(A) TFA is the active fragment of the secreted neuroprotective and glioprotective factor prosaposin (also known as sulfated glycoprotein-1)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1693.72

Formula

C71H111F3N16O28

Sequence

Thr-Ala-Leu-Ile-Asp-Asn-Asn-Ala-Thr-Glu-Glu-Ile-Leu-Tyr

Sequence Shortening

TALIDNNATEEILY

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Meyer RC, et al. GPR37 and GPR37L1 are receptors for the neuroprotective and glioprotective factors prosaptide and prosaposin. Proc Natl Acad Sci U S A. 2013;110(23):9529-9534.

    [2]. Campana WM, et al. Prosaptide activates the MAPK pathway by a G-protein-dependent mechanism essential for enhanced sulfatide synthesis by Schwann cells. FASEB J. 1998;12(3):307-314.