HXR9;
HXR9 是一种细胞渗透性肽,是 HOX/PBX 相互作用 (HOX/PBX interaction) 的竞争性拮抗剂。HXR9 拮抗 HOX 与第二转录因子 (PBX) 之间的相互作用,PBX 与旁系同源基因组 1 至 8 中的 HOX 蛋白结合。HXR9 选择性地减少细胞增殖并促进 HOXA/PBX3 基因高水平表达的细胞,例如 MLL 重排的白血病细胞中的细胞凋亡 (apoptosis)。
HXR9 Chemical Structure
CAS No. : 917953-08-3
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生物活性 |
HXR9 is a cell-permeable peptide and a competitive antagonist of HOX/PBX interaction. HXR9 antagonizes the interaction between HOX and a second transcrip-tion factor (PBX), which binds to HOX proteins in paralogue groups1 to 8. HXR9 selectively decreases cell proliferation and promotes apoptosis in cells with a high level of expression of the HOXA/PBX3 genes, such as MLL-rearranged leukemic cells[1][2][3]. |
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体外研究 (In Vitro) |
HXR9 (60μM; 4 hours) blocks the interaction between PBX and HOX[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. Western Blot Analysis
Apoptosis Analysis
RT-PCR
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体内研究 (In Vivo) |
HXR9 (10 mg/kg; i.v. via the tail vein; twice weekly) blocks tumor growth[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
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分子量 |
2718.21 |
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Formula |
C119H193N53O20S |
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CAS 号 |
917953-08-3 |
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Sequence |
Trp-Tyr-Pro-Trp-Met-Lys-Lys-His-His-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg-Arg |
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Sequence Shortening |
WYPWMKKHHRRRRRRRRR |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
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参考文献 |
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