Peptide C105Y;
Peptide C105Y,基于 α1-抗胰蛋白酶 359-374 残基氨基酸序列合成的细胞穿透性肽,能增强 DNA 纳米粒的基因表达。
Peptide C105Y Chemical Structure
CAS No. : 247572-63-0
规格 | 价格 | 是否有货 | |
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5 mg | ¥4000 | 询问价格 货期 | |
10 mg | ¥6800 | 询问价格 货期 |
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生物活性 |
Peptide C105Y, a synthetic and cell-penetrating peptide based on the amino acid sequence corresponding to residues 359-374 of α1-antitrypsin, enhances gene expression from DNA nanoparticles[1]. |
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体外研究 (In Vitro) |
When human hepatoma cells (HuH7) were incubated with fluorescently labeled C105Y for as little as 3 min, C105Y displays nuclear and cytoplasmic staining with enrichment of fluorescent signal in the nucleus and nucleolus. C105Y peptide is routed to the nucleolus very rapidly in an energy-dependent fashion, whereas membrane translocation and nuclear localization are energy-independent. When tested the involvement of known endocytosis pathways in uptake and trafficking of this peptide, C105Y peptide is internalized by a clathrin- and caveolin-independent pathway, although lipid raft-mediated endocytosis may play a role in peptide intracellular trafficking[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
1994.40 |
Formula |
C97H148N20O23S |
CAS 号 |
247572-63-0 |
Sequence |
Cys-Ser-Ile-Pro-Pro-Glu-Val-Lys-Phe-Asn-Lys-Pro-Phe-Val-Tyr-Leu-Ile |
Sequence Shortening |
CSIPPEVKFNKPFVYLI |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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