Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA

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Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA;

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) 是一种高亲和力的五肽，与 src SH2 域结合 (IC50≈1 µM)。Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA 是 src SH3-SH2：磷酸蛋白相互作用的抑制剂。

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFAamp;;

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA Chemical Structure

规格 是否有货
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生物活性

Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA (compound 1) is a high-affinity pentapeptide to bind to the src SH2 domain (IC50≈1 µM). Ac-Tyr(PO3H2)-Glu-Glu-Ile-Glu-OH TFA is an inhibitor for src SH3-SH2:phosphoprotein interactions[1].

分子量

917.73

Formula

C34H47F3N5O19P
Sequence Shortening

Ac–{Tyr(PO3H2)}-EEIE-OH
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. G J Pacofsky, et al. Potent dipeptide inhibitors of the pp60c-src SH2 domain. J Med Chem. 1998 May 21;41(11):1894-908.