[D-Trp34]-Neuropeptide Y TFA

发表于由

[D-Trp34]-Neuropeptide Y TFA;

[D-Trp34]-Neuropeptide Y TFA 是有效的，选择性神经肽 Y (NPY) Y5 受体激动剂。[D-Trp34]-Neuropeptide Y TFA 在 NPY Y1，Y2，Y4 和 y6 受体上的效力明显较低。[D-Trp34]-Neuropeptide Y TFA 明显增加大鼠的食物摄入量。

[D-Trp34]-Neuropeptide Y TFAamp;;

[D-Trp34]-Neuropeptide Y TFA Chemical Structure

规格 是否有货
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生物活性

[D-Trp34]-Neuropeptide Y TFA is a potent and selective neuropeptide Y (NPY) Y5 receptor agonist. [D-Trp34]-Neuropeptide Y TFA is a significantly less potent agonist at the NPY Y1, Y2, Y4, and y6 receptors. [D-Trp34]-Neuropeptide Y TFA markedly increases food intake in rats[1][2].

IC50 Target[1]

NPY Y5 receptor

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体外研究
(In Vitro)

[D-Trp34]-Neuropeptide Y TFA has pKi values of 6.49, 5.43, 7.08, 7.53, 6.55, 5.95, 6.85, 7.41 for hY1, hY2, hY4, hY5, rY1, rY2, rY4, rY5 in CHO cells. [D-Trp34]-Neuropeptide Y TFA has pEC50 values of 6.44, <6, 6.28，7.82 for rY1, rY2 in CHO cells and rY4, rY5 in HEK-293 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

[D-Trp34]-Neuropeptide Y TFA (0, 8 and 16 μg/rat; I.C.V) stimulats food intake to the same extent in both lean and obese rats 1 h after injection at a dose of 16 μg in male Zucker rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2466.76

Formula

C112H171F3N34O26
Sequence Shortening

YPSKPDNPGEDAPAEDLARYYSALRHYINLITR-{D-Trp}-RY-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. E M Parker, et al. [D-Trp(34)] neuropeptide Y is a potent and selective neuropeptide Y Y(5) receptor agonist with dramatic effects on food intake. Peptides. 2000 Mar;21(3):393-9.

    [2]. Bernard Beck, et al. Responsiveness of obese Zucker rats to [D-Trp34]-NPY supports the targeting of Y5 receptor for obesity treatment. Nutr Neurosci. Oct-Dec 2007;10(5-6):211-4.