[D-Arg25]-Neuropeptide Y (human) | Cytiva思拓凡-Whatman滤纸滤膜滤器

[D-Arg25]-Neuropeptide Y (human);

[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) 是 Y₁ 受体的选择性激动剂。Neuropeptide Y (human) 和阿尔兹海默症相关，能够保护老鼠皮质神经元对抗淀粉样蛋白毒性。

[D-Arg25]-Neuropeptide Y (human) Chemical Structure

规格		是否有货
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生物活性	[D-Arg25]-Neuropeptide Y (human) ([D-Arg25] NPY) is a Y₁ receptor selective agonist. Neuropeptide Y (human) is involved in Alzheimer’s disease (AD) and protects rat cortical neurons against β-Amyloid toxicity^[1].
体外研究 (In Vitro)	[D-Arg25]-NPY (1 μM) reversibly hyperpolarizes the membrane potential of hypocretin cells by 9.9 ± 1.4 mV (data not shown; p < 0.01; n = 10^[2]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)	Intracerebroventricular (icv) administration of [D-Arg25]NPY stimulates food intake in freely-feeding rats^[3]. MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量	4271.68
Formula	C₁₈₉H₂₈₅N₅₅O₅₇S
Sequence Shortening	YPSKPDNPGEDAPAEDMARYYSAL-{D-Arg}-HYINLITRQRY-NH2
运输条件	Room temperature in continental US; may vary elsewhere.
储存方式	Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献	[1]. Kilian Kuhn, et al. Molecular Tools for the NPY Y4 Receptor Derived from the C-Terminus of hPP and from Argininamide-type Y1R Antagonists. zur Erlangung des Doktorgrades der Naturwissenschaften an der Fakultät für Chemie und Pharmazie der Universität Regensburg. [2]. Li-Ying Fu, et al. Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system. J Neurosci. 2004 Oct 6;24(40):8741-51. [3]. Ambikaipakan Balasubramaniam, et al. Neuropeptide Y (NPY) family of hormones: progress in the development of receptor selective agonists and antagonists. Curr Pharm Des. 2003;9(15):1165-75.