GR 64349 TFA

发表于由

GR 64349 TFA;

GR 64349 是有效的、高度选择性的神经激肽 2 (NK2) 受体的肽类拮抗剂，其在大鼠结肠中测得的EC50 值为 3.7 nM。GR 64349 对 NK1 和 NK3 受体的选择性要低 1000 和 300 倍以上。

GR 64349 TFAamp;;

GR 64349 TFA Chemical Structure

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生物活性

GR 64349 is a potent and highly selective NK2 receptor peptide antagonist, with an EC50 of 3.7 nM in rat colon. GR 64349 exhibits selectivity >1000 and >300-fold with respect to NK1 and NK3 receptors, respectively[1][2].

分子量

1035.13

Formula

C44H69F3N10O13S
Sequence Shortening

KDSFV{Aaa}LM-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Y Chang, et al. Tachykinin receptor subtypes in the isolated guinea pig heart and their role in mediating responses to neurokinin A. J Pharmacol Exp Ther. 2000 Jul;294(1):147-54.

    [2]. M J Deal, et al. Conformationally constrained tachykinin analogues: potent and highly selective neurokinin NK-2 receptor agonists. J Med Chem. 1992 Oct 30;35(22):4195-204.