Angiotensinogen (1-14), human TFA

发表于由

Angiotensinogen (1-14), human TFA;

Angiotensinogen (1-14), human TFA 是肾素底物血管紧张素原 (angiotensinogen) 的片段，血管紧张素原是天然存在的肾素底物，也是所有血管紧张素肽的前体。

Angiotensinogen (1-14), human TFAamp;;

Angiotensinogen (1-14), human TFA Chemical Structure

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Angiotensinogen (1-14), human TFA 的其他形式现货产品:

Angiotensinogen (1-14), human

生物活性

Angiotensinogen (1-14), human TFA is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides[1][2].

IC50 Target[1][2]

Human Endogenous Metabolite

;

体外研究
(In Vitro)

Angiotensinogen (AGT) is the only precursor of all angiotensin peptides. Human AGT has 485 amino acids, including a 33 amino-acid signal peptide. The 10 N-terminal amino acids are cleaved by renin to provide angiotensin I (AngI), which is the source for an array of active angiotensin peptides[1].
Angiotensinogen isolated from most species is cleaved by human renin. Synthetic peptides containing the N-terminal amino-acid sequence of angiotensinogen were renin substrates[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1874.06

Formula

C85H123N24F3O21
Sequence Shortening

DRVYIHPFHLVIHN
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Lu H, et al. Structure and functions of angiotensinogen. Hypertens Res. 2016 Jul;39(7):492-500.

    [2]. Burton J, et al. The amino-acid residues on the C-terminal side of the cleavage site of angiotensinogeninfluence the species specificity of reaction with renin. iochim Biophys Acta. 1988 Jan 4;952(1):8-12.