Proadrenomedullin (1-20), human

发表于由

Proadrenomedullin (1-20), human;

Proadrenomedullin (1-20), human 是一种有效的降压和儿茶酚胺释放抑制肽，由嗜铬细胞释放，其抑制 PC12 嗜铬细胞瘤细胞儿茶酚胺分泌，IC50 值约为 ~350 nM，并以非竞争性的方式特别作用于烟碱胆碱能受体。

Proadrenomedullin (1-20), humanamp;;

Proadrenomedullin (1-20), human Chemical Structure

CAS No. : 150238-87-2

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生物活性

Proadrenomedullin (1-20), human is a potent hypotensive and catecholamine release–inhibitory peptide released from chromaffin cells with an IC50 of ~350 nM for catecholamine secretion in PC12 pheochromocytoma cells, acting in a noncompetitive manner specifically at the nicotinic cholinergic receptor[1].

分子量

2460.84

Formula

C112H178N36O27
CAS 号

150238-87-2
Sequence

Ala-Arg-Leu-Asp-Val-Ala-Ser-Glu-Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2
Sequence Shortening

ARLDVASEFRKKWNKWALSR-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Mahata M, et al. Proadrenomedullin N-terminal 20 peptide: minimal active region to regulate nicotinic receptors. Hypertension. 1998 Nov;32(5):907-16.