SAHM1

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SAHM1;

SAHM1 是一种显性阴性 MAML 形式的肽模拟物，可抑制经典 Notch 转录复合物的形成。SAHM1 可用于小鼠过敏性气道炎症的研究。

SAHM1amp;;

SAHM1 Chemical Structure

CAS No. : 2050906-89-1

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生物活性

SAHM1, a peptide mimetic of a dominant negative form of mastermind-like (MAML), inhibits canonical Notch transcription complex formation. SAHM1 can be used for the research of allergic airway inflammation in mice[1][2].

IC50 Target

Notch[1]
分子量

2196.58

Formula

C94H162N36O23S
CAS 号

2050906-89-1
Sequence Shortening

{Bal}ERLRRRI{Aaa}LCR{Aaa}HHST (Covalent bridge:Aaa9-Aaa13)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Ashley JW, et, al. Notch signaling promotes osteoclast maturation and resorptive activity. J Cell Biochem. 2015 Nov;116(11):2598-609.

    [2]. KleinJan A, et, al. The Notch pathway inhibitor stapled α-helical peptide derived from mastermind-like 1 (SAHM1) abrogates the hallmarks of allergic asthma. J Allergy Clin Immunol. 2018 Jul;142(1):76-85.e8.