Ac-RYYRWK-NH2 TFA;
Ac-RYYRWK-NH2 TFA 是一个有效的和选择性 nociceptin receptor (NOP) 部分激动剂。[3H]Ac-RYYRWK-NH2 TFA 结合鼠皮层膜的 ORL1 的Kd 为0.071 nM,但是对 µ-,κ- 或 δ 阿片受体没有亲和力。
Ac-RYYRWK-NH2 TFA Chemical Structure
CAS No. : 408305-09-9
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生物活性 |
Ac-RYYRWK-NH2 is a potent and selective partial agonist for the nociceptin receptor (NOP), [3H]Ac-RYYRWK-NH2 binds to rat cortical membranes ORL1 with a Kd of 0.071 nM, but has no affinity for µ-, κ- or δ-opioid receptors[1]. |
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体外研究 (In Vitro) |
[3H]ac-RYYRWK-NH2 binding to rat cortical membranes revealed a single high affinity site for [3H]ac-RYYRWK-NH2 (Kd=0.071 nM)[1]. Naloxone benzoylhydrazone displaced [3H]acRYYRWK-NH2 binding to rat cortical membranes (Ki=104 nM) and human ORL1 (Ki=136 nM) as well as [125I]Tyr14-NC-OH to ORL1 (Ki=37 nM) has no affinity for µ-, κ- or δ-opioid receptors[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
分子量 |
1126.19 |
Formula |
C51H70F3N15O11 |
CAS 号 |
408305-09-9 |
Sequence Shortening |
Ac-RYYRWK-NH2 |
运输条件 |
Room temperature in continental US; may vary elsewhere. |
储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
参考文献 |
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