CKLF1-C27 TFA

发表于由

CKLF1-C27 TFA;

CKLF1-C27 是 CKLF1 的 C 末端肽，与 CCR4 受体结合并激活 ERK1/2 通路。CKLF1-C27 可以通过竞争 CCR4 受体来消除 CKLF1 对细胞的影响。CKLF1-C27对促进HUVECs增殖有很大的作用。CKLF1-C27 具有用于银屑病研究的潜力。

CKLF1-C27 TFAamp;;

CKLF1-C27 TFA Chemical Structure

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生物活性

CKLF1-C27, a C-terminal peptide of CKLF1, binds to CCR4 receptor and activates ERK1/2 pathway. CKLF1-C27 can abrogate the effect of CKLF1 on cells by competing for CCR4 receptor. CKLF1-C27 shows great effect on promoting proliferation on HUVECs. CKLF1-C27 has the potential for psoriasis research[1].

IC50 Target[1]

CCR4

;

ERK1

;

ERK2

;

分子量

3310.80

Formula

C153H244F3N39O39
Sequence Shortening

ALIYRKLLFNPSGPYQKKPVHEKKEVL
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Yaqi Tan, et al. Chemokine-like factor 1-derived C-terminal peptides induce the proliferation of dermal microvascular endothelial cells in psoriasis. PLoS One. 2015 Apr 27;10(4):e0125073.