β-Casomorphin, bovine TFA (β-Casomorphin-7 (bovine) TFA) is a opioid peptide with an IC50 of 14 μM in an Opioid receptors binding assay[1].
IC50 Target
IC50: 14 μM (Opioid receptor)[1]
体外研究 (In Vitro)
β-Casomorphin, bovine TFA (0.1μM; 30 minutes-24 hours) stimulates the secretion of mucin in DHE Cells after 8 h of treatment[2]. β-Casomorphin, bovine TFA (0.1μM; 24 hours) induces an increase in rMuc2 and rMuc3 mRNA levels[2]. β-Casomorphin, bovine TFA does not modify the expression of rMuc1, rMuc4, and rMuc5AC[2]. β-Casomorphin, bovine TFA (0.1μM; 24 hours) stimulates MUC5AC expression and mucin Secretion in HT29-MTX Cells (human)[2].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究 (In Vivo)
β-Casomorphin, bovine TFA (7.5×10−6 mol/day/kg ; i.g.; for 30 days) increases plasma insulin and decreased plasma glucagon of diabetic rats[3]. β-Casomorphin, bovine TFA (7.5×10−6 mol/day/kg ; i.g.; for 30 days) alters the changes of SOD, GPx, T-AOC, MDA and H2O2 in the kidney of diabetic rats[3]. β-Casomorphin, bovine TFA (7.5×10−6 mol/day/kg ; i.g.; for 30 days) reduces MDA (significantly) and H2O2 (non-significantly) level in the kidney compared to the diabetic rats[3]. β-Casomorphin, bovine TFA (7.5×10−6 mol/day/kg ; i.g.; for 30 days) alleviates high glucose-induced decreasement in SOD and GPx activity, increasement in MDA contents in the NRK-52E cells[3].
MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Animal Model:
Male Sprague-Dawley (SD) rats (200 g±10 g)[3]
Dosage:
7.5×10−6 mol/day/kg
Administration:
Oral gavage; for 30 days
Result:
Increased plasma insulin and decreased plasma glucagon of diabetic rats.
分子量
903.94
Formula
C43H56F3N7O11
Sequence
Tyr-Pro-Phe-Pro-Gly-Pro-Ile
Sequence Shortening
YPFPGPI
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献
[1]. Brantl V, et al. Opioid activities of beta-casomorphins. Life Sci. 1981 Apr 27;28(17):1903-9.
[2]. Zoghbi S, et al. β-casomorphin-7-7 regulates the secretion and expression of gastrointestinal mucins through a μ-opioid pathway. Am J Physiol Gastrointest Liver Physiol. 2006 Jun;290(6):G1105-13.
[3]. Zhang W, et al. The protective effects of beta-casomorphin-7 against glucose -induced renal oxidative stress in vivo and vitro. PLoS One. 2013 May 3;8(5):e63472.