PEN (rat)

发表于由

PEN (rat);

PEN (rat) 是由 ProSAAS 原蛋白衍生而来的最丰富的下丘脑神经肽之一，是 GPR83 的内源性配体。

PEN (rat)amp;;

PEN (rat) Chemical Structure

CAS No. : 569364-13-2

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生物活性

PEN (rat), one of the most abundant hypothalamic neuropeptide and derived from the proprotein ProSAAS, is an endogenous ligand of GPR83[1].

体外研究
(In Vitro)

Mouse PEN (mPEN) and rat PEN (rPEN) only differ by one residue at the N-terminal end, whereas human PEN (hPEN) is more divergent and has the sequence PEG instead of PEN[2].
PEN binds and activates a GPCR in the brain[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2301.59

Formula

C102H169N27O33
CAS 号

569364-13-2
Sequence Shortening

AVDQDLGPEVPPENVLGALLRV
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Seshat M Mack, et al. Neuropeptide PEN and Its Receptor GPR83: Distribution, Signaling, and Regulation. ACS Chem Neurosci. 2019 Apr 17;10(4):1884-1891.

    [2]. Ivone Gomes, et al. Identification of GPR83 as the receptor for the neuroendocrine peptide PEN. Sci Signal. 2016 Apr 26;9(425):ra43.