[Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA)

发表于由

[Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA);

[Ala1,3,11,15]-Endothelin (53-63) (TFA) 是一种内皮素 (ET)-1 的线性肽类似物，对内皮素 B (ETB) 受体具有高度选择性。

[Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA)amp;;

[Ala1,​3,​11,​15]​-​Endothelin (53-63) (TFA) Chemical Structure

规格 是否有货
5 mg 询价

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生物活性

[Ala1,3,11,15]-Endothelin (53-63) (TFA), a linear peptide analog of endothelin (ET)-1, is a highly selective endothelin B (ETB) receptor[1].

IC50 Target[1]

ETB

;

体外研究
(In Vitro)

[Ala1,3,11,15]-Endothelin (53-63) (TFA) has IC50s of 0.61 nM, 0.61 nM, 0.33 nM, 2200 nM for ETB in Bronchus, Lung, Cerebellum, VSMC, respectively[1].
[Ala1,3,11,15]-Endothelin (53-63) (TFA) inhibits the specific binding of [125I]ET-1 with IC50s of 0.61 nM in bronchus and lung parenchyma[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

2481.70

Formula

C111H164F3N25O34S
Sequence

Ala-Ser-Ala-Ser-Ser-Leu-Met-Asp-Lys-Glu-Ala-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp
Sequence Shortening

ASASSLMDKEAVYFAHLDIIW
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Nakamichi K, et al. Different distribution of endothelin receptor subtypes in pulmonary tissues revealed by the novel selective ligands BQ-123 and [Ala1,3,11,15]ET-1. Biochem Biophys Res Commun. 1992 Jan 15;182(1):144-50.

    [2]. T Saeki, et al. [Ala1,3,11,15]endothelin-1 Analogs With ETB Agonistic Activity. Biochem Biophys Res Commun. 1991 Aug 30;179(1):286-92.