CVT-11127(Synonyms: GS-456332)

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CVT-11127;(Synonyms: GS-456332)

CVT-11127 是一种有效的 SCD 抑制剂。CVT-11127 诱导细胞凋亡 apoposis 并将细胞周期阻滞在 G1/S 期。 CVT-11127具有肺癌研究潜力。

CVT-11127amp;;(Synonyms: GS-456332)

CVT-11127 Chemical Structure

CAS No. : 1018674-83-3

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生物活性

CVT-11127 is a potent SCD inhibitor. CVT-11127 induces apoposis and arrests the cell cycle at the G1/S phase. CVT-11127 has the potential for the research of lung cancer[1].

IC50 Target

SCD[1]
体外研究
(In Vitro)

CVT-11127 (1 µM, 48 h) shows antiproliferation activity in H460 cells[1].
CVT-11127 (1 µM, 48 h) decreases the the population of cells in S-phase by 75%[1].
CVT-11127 (1 µM, 48 h) induces apoposis in H460 cells[1].
CVT-11127 (1, 2 µM) inhibitors the SCD (stearoylCoA desaturase) activity in H460 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 48 h
Result: Showed antiproliferation activity.

Cell Cycle Analysis[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 48 h
Result: Decreased the the population of cells in S-phase by 75%.

Apoptosis Analysis[1]

Cell Line: H460 cells
Concentration: 1 µM
Incubation Time: 24 h
Result: Induced apoposis H460 cells.

分子量

512.39

Formula

C25H23Cl2N5O3
CAS 号

1018674-83-3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
参考文献

  • [1]. Hess D,et al. Inhibition of stearoylCoA desaturase activity blocks cell cycle progression and induces programmed cell death in lung cancer cells. PLoS One. 2010; 5(6):e11394.