Ac-hMCH(6-16)-NH2

Ac-hMCH(6-16)-NH2;

Ac-hMCH(6-16)-NH2 是人脑中 MCH 的非选择性肽类激动剂,其对MCH-1R 和MCH-2R 的 IC50 值分别为 0.16 nM 和2.7 nM。

Ac-hMCH(6-16)-NH2amp;;

Ac-hMCH(6-16)-NH2 Chemical Structure

CAS No. : 1053601-50-5

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生物活性

Ac-hMCH(6-16)-NH2 binds to and activates equally well both human MCH receptors present in the brain (non-selective agonist), with IC50 values of 0.16 nM and 2.7 nM for MCH-1R and MCH-2R[1].

体外研究
(In Vitro)

Ac-hMCH(6-16)-NH2 exhibits EC50 values of 20 nM and 98 nM for MCH-1R and MCH-2R in aequorin functional assay, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1394.73

Formula

C58H99N21O13S3

CAS 号

1053601-50-5

Sequence

Ac-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-NH2

Sequence Shortening

Ac-RCMLGRVYRPC-NH2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • [1]. Maria A Bednarek, et al. Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. J Biol Chem. 2002 Apr 19;277(16):13821-6.