Conopressin S(Synonyms: Con-S)

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Conopressin S;(Synonyms: Con-S)

Conopressin S 是从Conus striatus 中分离出来的一种多肽，能与血管加压素V1b 受体 (AVPR1B) 高亲和力结合，Ki 值为8.3 nM。

Conopressin Samp;;(Synonyms: Con-S)

Conopressin S Chemical Structure

CAS No. : 111317-90-9

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生物活性

Conopressin S, isolated from Conus striatus, shows high affinity with vasopressin V1b receptor (AVPR1B), with a Ki of 8.3 nM[1].

IC50 Target

Ki: 8.3 nM (AVPR1B)[1].
Clinical Trial

分子量

1028.26

Formula

C41H73N17O10S2
CAS 号

111317-90-9
Sequence

Cys-Ile-Ile-Arg-Asn-Cys-Pro-Arg-Gly-NH2(Disulfide bridge: Cys1-Cys6)
Sequence Shortening

CIIRNCPRG-NH2 (Disulfide bridge: Cys1-Cys6)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent Solubility
In Vitro:;

H2O

Peptide Solubility and Storage Guidelines:

1.;;Calculate the length of the peptide.

2.;;Calculate the overall charge of the entire peptide according to the following table:

; Contents Assign value
Acidic amino acid Asp (D), Glu (E), and the C-terminal -COOH. -1
Basic amino acid Arg (R), Lys (K), His (H), and the N-terminal -NH2 +1
Neutral amino acid Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q) 0

3.;;Recommended solution:

Overall charge of peptide Details
Negative (lt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, add NH4OH (lt;50 μL).
3.;;If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (gt;0) 1.;;Try to dissolve the peptide in water first.
2.;;If water fails, try dissolving the peptide in a 10%-30% acetic acid solution.
3.;;If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0) 1.;;Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first.
2.;;For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.
参考文献

  • [1]. Dutertre S, et al. Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. J Biol Chem. 2008 Mar 14;283(11):7100-8.