Fz7-21;(Synonyms: Ac-LPSDDLEFWCHVMY-NH2)
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2) 是 Frizzled 7 (FZD 7) 受体的肽抑制剂，选择性地与 FZD7 CRD 亚类结合。在人和小鼠 FZD7 CRD 中的 EC50 值分别为 58 和 34 nM。Fz7-21 对外源性 WNT3A (IC50=100 nM) 刺激和转染 WNT3A 或 WNT1 的 HEK293 细胞 Wnt/β-catenin 信号传导有损伤。Fz7-21 还阻断了 WNT3A 介导的 β-catenin 在小鼠 L 细胞中的稳定作用 (IC50=50 nM)。
Fz7-21 Chemical Structure
CAS No. : 2247635-23-8
| 规格 | 是否有货 | ||
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| 100 mg | ; | 询价 | ; |
| 250 mg | ; | 询价 | ; |
| 500 mg | ; | 询价 | ; |
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Fz7-21 的其他形式现货产品:
| 生物活性 |
Fz7-21 (Ac-LPSDDLEFWCHVMY-NH2), a peptide antagonist of Frizzled 7 (FZD 7) receptors, selectively binds to FZD7 CRD subclass. The EC50 values are 58 and 34 nM for human and mouse FZD7 CRD, respectively. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM)[1]. |
IC50 Target |
EC50: 58 nM (human FZD7 CRD), 34 nM (mouse FZD7 CRD)[1] |
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| 分子量 |
1796.05 |
| Formula |
C83H114N18O23S2 |
| CAS 号 |
2247635-23-8 |
| Sequence Shortening |
Ac-LPSDDLEFWCHVMY-NH2 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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