Goserelin acetate(Synonyms: 醋酸戈舍瑞林 ICI-118630 acetate)

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Goserelin acetate;(Synonyms: 醋酸戈舍瑞林; ICI-118630 acetate) 纯度: 99.23%

Goserelin acetate (ICI-118630 acetate) 是一种促性腺激素释放激素 (GnRH/LHRH) 十肽类似物，能作为 GnRH 激动剂。Goserelin acetate 可用于乳腺癌、上皮性卵巢癌和前列腺癌的研究。

Goserelin acetateamp;;(Synonyms: 醋酸戈舍瑞林; ICI-118630 acetate)

Goserelin acetate Chemical Structure

CAS No. : 145781-92-6

规格 价格 是否有货 数量
10;mM;*;1 mL in DMSO ￥1930 In-stock
5 mg ￥910 In-stock
10 mg ￥1320 In-stock
50 mg ￥4620 In-stock
100 mg ; 询价 ;
200 mg ; 询价 ;

* Please select Quantity before adding items.

Goserelin acetate 相关产品

bull;相关化合物库:

  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • FDA-Approved Drug Library Mini
  • Bioactive Compound Library Plus
  • Apoptosis Compound Library
  • GPCR/G Protein Compound Library
  • FDA-Approved Drug Library
  • Anti-Cancer Compound Library
  • Drug Repurposing Compound Library
  • Endocrinology Compound Library
  • FDA Approved amp; Pharmacopeial Drug Library
  • Anti-Breast Cancer Compound Library
  • Drug-Induced Liver Injury (DILI) Compound Library
  • Targeted Diversity Library
  • Rare Diseases Drug Library
  • Peptide Library

生物活性

Goserelin acetate (ICI-118630 acetate), a decapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH), functions as a GnRH agonist. Goserelin acetate can be used for the research of breast cancer, epithelial ovarian cancer and prostate cancer[1][2].

IC50 Target

GnRH[1]
体外研究
(In Vitro)

Goserelin (1 nM-1 mM; 48-72 hours) promotes EOC cell apoptosis[1].
Goserelin (100 μM; 24-72 hours) regulates the expression of human apoptosis-related genes in SKOV3-ip cells[1].
Goserelin (100 μM; 24-72 hours) promotes EOC cell apoptosis by upregulating FOXO1 through the PI3K/AKT signaling pathway[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis[1]

Cell Line: SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
Concentration: 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM
Incubation Time: 48 hours, 72 hours
Result: Significantly increased the total apoptosis rate of SKOV3-ip, SKOV3 and A2780 cells.

Western Blot Analysis[1]

Cell Line: SKOV3 cells, SKOV3-ip cells, A2780 cells (human EOC cell lines)
Concentration: 1 nM, 10 nM, 100 nM, 1 μM, 10 μM, 100 μM, 1 mM
Incubation Time: 48 hours, 72 hours
Result: The expression of cleaved-caspase-3 and cleaved-PARP were observably increased at 100 μM.

RT-PCR[1]

Cell Line: SKOV3-ip cells
Concentration: 100 μM
Incubation Time: 24 hours, 48 hours, 72 hours
Result: Expression of human apoptosis-related genes regulated

体内研究
(In Vivo)

Goserelin (100 µg; s.c.; daily; for 19 days) significantly increases the proportion of apoptotic cells in the subcutaneous xenograft tumors[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five-week-old specific-pathogen free (SPF) female nude mice (18-20 g), subcutaneous xenograft tumor model[1]
Dosage: 100 µg/mice
Administration: Subcutaneous injection, daily, for 19 days
Result: Significantly increased the proportion of apoptotic cells in the subcutaneous xenograft tumors

Clinical Trial

分子量

1329.46

Formula

C61H88N18O16
CAS 号

145781-92-6
中文名称

醋酸戈舍瑞林
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80deg;C 2 years
-20deg;C 1 year

*In solvent : -80deg;C, 6 months; -20deg;C, 1 month (sealed storage, away from moisture)
溶解性数据
In Vitro:;

H2O : 100 mg/mL (75.22 mM; Need ultrasonic)

DMSO : ≥ 28 mg/mL (21.06 mM)

* “≥” means soluble, but saturation unknown.

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 0.7522 mL 3.7609 mL 7.5219 mL
5 mM 0.1504 mL 0.7522 mL 1.5044 mL
10 mM 0.0752 mL 0.3761 mL 0.7522 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 1.

    请依序添加每种溶剂：;10% DMSO ;; 40% PEG300 ;; 5% Tween-80 ;; 45% saline

    Solubility: ≥ 2.08 mg/mL (1.56 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (1.56 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；向上述体系中加入50 μL Tween-80，混合均匀；然后继续加入 450 μL生理盐水定容至 1 mL。

    将 0.9 g 氯化钠，完全溶解于 100 mL ddH₂O 中，得到澄清透明的生理盐水溶液

  • 2.

    请依序添加每种溶剂：;10% DMSO ;; 90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (1.56 mM); Clear solution

    此方案可获得 ≥ 2.08 mg/mL (1.56 mM，饱和度未知) 的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液中，混合均匀。

    将 2 g 磺丁基醚 β-环糊精加入 5 mL 生理盐水中，再用生理盐水定容至 10 mL，完全溶解，澄清透明
  • 3.

    请依序添加每种溶剂：;10% DMSO ;; 90% corn oil

    Solubility: 2.08 mg/mL (1.56 mM); Clear solution; Need warming

    此方案可获得 2.08 mg/mL (1.56 mM) 的澄清溶液，此方案不适用于实验周期在半个月以上的实验。

    以 1 mL 工作液为例，取 100 μL 20.8 mg/mL 的澄清 DMSO 储备液加到 900 μL玉米油中，混合均匀。

*以上所有助溶剂都可在 MCE 网站选购。
参考文献

  • [1]. Ning Zhang, et al. Goserelin promotes the apoptosis of epithelial ovarian cancer cells by upregulating forkhead box O1 through the PI3K/AKT signaling pathway. Oncol Rep. 2018 Mar; 39(3): 1034–1042.

    [2]. Halle C F Moore, et al. Goserelin for ovarian protection during breast-cancer adjuvant chemotherapy. N Engl J Med. 2015 Mar 5;372(10):923-32.