上海金畔生物科技有限公司提供天然产物萜类及其苷类Terpenoids and Glycosides。
Gymnestrogenin (Synonyms: 匙羹藤苷元)
Gymnestrogenin 是来自 Gymnema sylvestre R.Br. 叶片的五羟基三萜。Gymnestrogenin 是一种有效的 LXR 拮抗剂，对 LXRα 和 LXRβ 反式激活的 IC50 分别为 2.5 和 1.4 μM。Gymnestrogenin 在其自身的启动子上也会降低 LXR 的转录活性，从而降低 mRNA 的表达。
Gymnestrogenin Chemical Structure
CAS No. : 19942-02-0
| 规格 | 是否有货 | ||
|---|---|---|---|
| 5 mg | 询价 | ||
| 10 mg | 询价 | ||
| 25 mg | 询价 |
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| 生物活性 |
Gymnestrogenin is a pentahydroxytriterpene from the leaves of Gymnema sylvestre R.Br[1]. Gymnestrogenin is a LXR antagonist with IC50s of 2.5 and 1.4 μM for LXRα and LXRβ transactivation, respectively. Gymnestrogenin reduces the transcriptional activity of LXR even on its own promoter, thus reducing the mRNA expression[2]. |
IC50 & Target |
IC50: 2.5 μM (LXRα) and 1.4 μM (LXRβ)[2] |
|---|---|
| 体外研究 (In Vitro) |
Gymnestrogenin, reducing the expression of SREBP1c and ABCA1 in vitro, is able to decrease lipid accumulation in HepG2 cells[2]. Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only. |
| 分子量 |
490.72 |
| Formula |
C30H50O5 |
| CAS 号 |
19942-02-0 |
| 中文名称 |
匙羹藤苷元 |
| 运输条件 |
Room temperature in continental US; may vary elsewhere. |
| 储存方式 |
Please store the product under the recommended conditions in the Certificate of Analysis. |
| 参考文献 |
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