Dihydroisotanshinone I(Synonyms: 二氢异丹参酮I)

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天然产物醌类Quinones

Dihydroisotanshinone I (Synonyms: 二氢异丹参酮I) 纯度: 99.52%

Dihydroisotanshinone I 是丹参中的一种生物活性化合物，可抑制雄激素依赖性和雄激素非依赖性前列腺癌细胞的迁移。Dihydroisotanshinone I 还诱导这些肺癌细胞的凋亡 (apoptosis) 和铁死亡 (ferroptosis)。Dihydroisotanshinone I 还阻断 GPX4 的蛋白表达。

Dihydroisotanshinone I(Synonyms: 二氢异丹参酮I)

Dihydroisotanshinone I Chemical Structure

CAS No. : 20958-18-3

规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥2380 In-stock
5 mg ￥1800 In-stock
10 mg ￥2800 In-stock
25 mg ￥5800 In-stock
50 mg ￥9800 In-stock
100 mg   询价  
200 mg   询价  

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Dihydroisotanshinone I 相关产品

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生物活性

Dihydroisotanshinone I, a bioactive compound present in danshen, can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells. Dihydroisotanshinone I also induces apoptosis and ferroptosis in these lung cancer cells. Dihydroisotanshinone I also blocks the protein expression of GPX4[1][2].

IC50 & Target[1]

STAT3

 

体外研究
(In Vitro)

Dihydroisotanshinone I inhibits the protein expression of p-STAT3 and blocked the translocation of STAT3 into the chromatin, as well as suppressed tumor epithelial–mesenchymal transition (EMT) gene expression[1].
Dihydroisotanshinone I (10-30 μM; 24 huors) has inhibitory effects on the growth of the lung cancer cell lines, A549 cells and H460 cells[2].
Dihydroisotanshinone I (20-30 μM; 24 huors) induces pronounced apoptosis in A549 and H460 cells in a dose-dependent manner[2].
Dihydroisotanshinone I can induce ferroptosis in lung cancer cells[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.
体内研究
(In Vivo)

Dihydroisotanshinone I (30 mg/kg; intraperitoneally; every 2 days for 18 days) can inhibit metastasis of A549 cells in the nude mice model without adverse effects on mice[2].

Shanghai Jinpan Biotech Co Ltd has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (beraing A549 cells) [2]
Dosage: 30 mg/kg
Administration: Intraperitoneally; every 2 days for 18 days
Result: Inhibited A549 cell metastasis in nude mice without adverse effects.

分子量

278.30

Formula

C18H14O3
CAS 号

20958-18-3
中文名称

二氢异丹参酮I
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO : 3.33 mg/mL (11.97 mM; ultrasonic and warming and heat to 40°C)

H2O : 1 mg/mL (3.59 mM; ultrasonic and warming and heat to 80°C)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 3.5932 mL 17.9662 mL 35.9324 mL
5 mM 0.7186 mL 3.5932 mL 7.1865 mL
10 mM 0.3593 mL 1.7966 mL 3.5932 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。