天然产物 糖类和糖苷 Saccharides and Glycosides
Gastrodin;(Synonyms: Gastrodine) 纯度: 99.14%
Gastrodin 是中草药天麻的主要成分,具有抗炎作用。Gastrodin 长期以来一直用于头晕,癫痫,中风和痴呆症的研究。
Gastrodin Chemical Structure
CAS No. : 62499-27-8
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10;mM;*;1 mL in DMSO | ¥550 | In-stock | |
25 mg | ¥500 | In-stock | |
50 mg | ¥800 | In-stock | |
100 mg | ¥1400 | In-stock | |
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Gastrodin 相关产品
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生物活性 |
Gastrodin, a main constituent of a Chinese herbal medicine Tianma, has been known to display anti-inflammatory effects. Gastrodin, has long been used for treating dizziness, epilepsy, stroke and dementia. |
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体外研究 (In Vitro) |
Gastrodin treatment reduces the mRNA expression levels of TNF-α and iNOS in the retinas of acute ocular hypertension[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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体内研究 (In Vivo) |
Intraperitoneal injection with Gastrodin 10 mg/kg or 50 mg/kg once daily for 15 d significantly inhibits the loss of retinal ganglion cells (RGCs) because of acute ocular hypertension (AOH) damage. 2 wk after AOH, the number of Iba1 positive retinal microglia obviously reduces to 231.3±54.3 cells/mm2 and 201.9±43.1 cells/mm2 in the rats intraperitoneally injected with Gastrodin at 10 mg/kg and 50 mg/kg, respectively[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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分子量 |
286.28 |
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Formula |
C13H18O7 |
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CAS 号 |
62499-27-8 |
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运输条件 |
Room temperature in continental US; may vary elsewhere. |
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储存方式 |
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溶解性数据 |
In Vitro:;
DMSO : ≥ 100 mg/mL (349.31 mM) H2O : 100 mg/mL (349.31 mM; Need ultrasonic) * “≥” means soluble, but saturation unknown. 配制储备液
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请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo:
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用; 以下溶剂前显示的百
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参考文献 |
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Cell Assay [1] |
Retinas are collected at day 14 postoperatively, following treatment with normal saline (NS) or various doses of Gastrodin. The mRNA expression levels of TNF-α and iNOS are determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR)[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
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Animal Administration [1] |
Adult female SD rats (age, 8 wk; weight, 200 to 250 g) are used. The rats are divided into 4 groups: 1) control group; 2) normal saline (NS) group who are exposed to acute ocular hypertension (AOH) and receive intraperitoneal injection of 0.9% NS; 3) G10 group who are exposed to AOH and receive intraperitoneal injection of 10 mg/kg Gastrodin; 4) G50 group who are exposed to AOH and receive intraperitoneal injection of 50 mg/kg Gastrodin. The loss of retinal ganglion cells (RGCs) and the number of Iba1-positive retina microglia are determined at 2 wk after rapid ocular hypertension[1]. MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
参考文献 |
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