Glucosamine(Synonyms: 氨基葡萄糖; D-Glucosamine; Chitosamine)

发表于由

天然产物 糖类和糖苷 Saccharides and Glycosides

Glucosamine;(Synonyms: 氨基葡萄糖; D-Glucosamine; Chitosamine) 纯度: ge;98.0%

Glucosamine (D-Glucosamine) 是一种氨基糖, 是糖基化蛋白和脂质生化合成的突出前体, 用作膳食补充剂。Glucosamine 也是软骨基质和滑液中糖胺聚糖的天然成分，当外用时，对骨关节炎软骨和软骨细胞具有药理作用。

Glucosamine(Synonyms: 氨基葡萄糖; D-Glucosamine; Chitosamine)

Glucosamine Chemical Structure

CAS No. : 3416-24-8

规格 价格 是否有货 数量
100 mg ￥2250 In-stock
200 mg ; 询价 ;
500 mg ; 询价 ;

* Please select Quantity before adding items.

Glucosamine 相关产品

bull;相关化合物库:

  • Covalent Screening Library Plus
  • Natural Product Library Plus
  • Drug Repurposing Compound Library Plus
  • FDA-Approved Drug Library Plus
  • FDA-Approved Drug Library Mini
  • Bioactive Compound Library Plus
  • Epigenetics Compound Library
  • Immunology/Inflammation Compound Library
  • Metabolism/Protease Compound Library
  • NF-kappa;B Signaling Compound Library
  • Stem Cell Signaling Compound Library
  • Natural Product Library
  • FDA-Approved Drug Library
  • Autophagy Compound Library
  • Human Endogenous Metabolite Compound Library
  • Anti-Aging Compound Library
  • Drug Repurposing Compound Library
  • Covalent Screening Library
  • Antioxidants Compound Library
  • Reprogramming Compound Library
  • Oxygen Sensing Compound Library
  • Ferroptosis Compound Library
  • Anti-COVID-19 Compound Library
  • NMPA-Approved Drug Library
  • Pyroptosis Compound Library
  • Glutamine Metabolism Compound Library
  • FDA Approved amp; Pharmacopeial Drug Library
  • Anti-Breast Cancer Compound Library
  • Drug-Induced Liver Injury (DILI) Compound Library
  • Anti-Cancer Metabolism Compound Library
  • Angiogenesis Related Compound Library
  • Mitochondria-Targeted Compound Library
  • Transcription Factor Targeted Library
  • Food-Sourced Compound Library
  • Rare Diseases Drug Library
  • Childrenrsquo;s Drug Library

生物活性

Glucosamine (D-Glucosamine) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes[1].

IC50 Target

Human Endogenous Metabolite

;

体外研究
(In Vitro)

Glucosamine (D-Glucosamine) exhibits dose-dependent DPPH antioxidant activity[2].
Glucosamine treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins[3].
Glucosamine significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial

分子量

179.17

Formula

C6H13NO5
CAS 号

3416-24-8
中文名称

葡糖胺；葡萄糖胺；氨基葡萄糖；D-氨基葡萄糖
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20deg;C 3 years
4deg;C 2 years
In solvent -80deg;C 6 months
-20deg;C 1 month
溶解性数据
In Vitro:;

H2O : 100 mg/mL (558.13 mM; Need ultrasonic)

DMSO : 3.33 mg/mL (18.59 mM; Need ultrasonic)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 5.5813 mL 27.9065 mL 55.8129 mL
5 mM 1.1163 mL 5.5813 mL 11.1626 mL
10 mM 0.5581 mL 2.7906 mL 5.5813 mL

*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
参考文献

  • [1]. Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S12-7.

    [2]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9.

    [3]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706.

    [4]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84.